Results 21 to 30 of about 15,889 (189)

Establishment of a TNFRSF11B knock-out human induced pluripotent stem cell line (KSCBi002-B-2) via CRISPR/Cas9 system

Stem Cell Research, 2023
A TNFRSF11B (TNF Receptor Superfamily Member 11b) gene encodes a soluble decoy receptor, osteoprotegerin (OPG), which has a key role in repressing osteoclast differentiation. In this report, we generated a biallelic knock-out hiPSC line for the TNFRSF11B
Jujin Jeong, Dahye Lee, Byeong-Cheol Park, Tae-Hoon Lee, Sang-Wook Park   +4 more
doaj   +1 more source

Pigmented Paget′s disease of nipple: A diagnostic challenge on cytology

Journal of Cytology, 2013
Paget′s disease is a rare form of breast cancer often associated with an underlying ductal carcinoma in situ or invasive cancer. A 47-year-old female patient presented with bleeding from the left nipple since 4 months.
B R Vani, M U Thejaswini, V Srinivasamurthy, M Sudha Rao   +3 more
doaj   +1 more source

Pigmentary Mammary Paget Disease: clinical, dermoscopical and histological challenge

Dermatology Reports, 2021
A very rare variant of MPD is the Pigmented Mammary Paget Disease (PMPD), first described by Culberson et al. in 1956. It is very difficult to distinguish this variant from melanoma both clinically and dermoscopically.
Angelo Massimiliano D'Erme, Roberta Iozzo, Paolo Viacava, Agata Janowska, Valentina Dini, Marco Romanelli, Cristian Fidanzi, Giovanni Bagnoni   +7 more
doaj   +1 more source

Paget's Disease of Bone [PDF]

New England Journal of Medicine, 1993
Paget's disease of bone may present with bone pain but is often asymptomatic. Treatment (typically with bisphosphonates) is indicated in patients with pain that is localized to an affected site but not in asymptomatic patients.
openaire   +3 more sources

Vulvar Paget disease secondary to high-grade urothelial carcinoma with underlying massive vascular embolization and cervical involvement: case report of unusual presentation

Diagnostic Pathology, 2019
Background Vulvar extramammary Paget disease is a rare chronic condition, that presents with non-specific symptoms such as pruritus and eczematous lesions. Because most of these lesions are noninvasive, the distinction between primary and secondary Paget
Walquiria Quida Salles Pereira Primo, Guttenberg Rodrigues Pereira Primo, Dunya Bachour Basilio, Karime Kalil Machado, Jesus Paula Carvalho, Filomena M. Carvalho   +5 more
doaj   +1 more source

Paget bone disease demonstrated on 18F-fluorocholine PET/CT: a case report [PDF]

Beyond Rheumatology, 2020
Paget disease (PD) is a chronic disorder resulting in enlarged and misshapen bones, caused by disorganized bone remodeling. This case involves a 64-year-old man with prostatic adenocarcinoma and PD of some skeletal areas with increased uptake shown on 18
Antonella Laria, Alfredomaria Lurati, Katia Angela Re, Mariagrazia Marrazza, Daniela Mazzocchi, Paola Maria Faggioli, Antonino Mazzone   +6 more
doaj   +1 more source

Beyond the Ordinary: A Surgical Approach to Perianal Paget Disease

Journal of Coloproctology
Perianal Paget Disease (PPD) is a rare form of extramammary Paget disease characterized by erythematous or eczematous plaques in the perianal region. Its rarity and resemblance to benign skin conditions often result in delayed diagnosis.
Rita Ribeiro Dias, André Gonçalves, Joana Costa, Pedro Organista Machado, Eliane Jaconiano, Daniela Marinheiro Silva, Miguel Machado, Carolina Leal, Silvestre Carneiro   +8 more
doaj   +1 more source

Extra mammary Paget′s disease: A rare case report

Indian Journal of Dermatology, 2015
Extramammary Paget′s disease is a marginated plaque resembling Paget′s disease but occurring in anogenital area, axilla or most commonly on the vulva. A 62-year-old postmenopausal woman presented with extremely pruritic plaque on the perineal skin which ...
Vidyadhar R Sardesai, Trupti D Agarwal, Sarita P Sakhalkar   +2 more
doaj   +1 more source

Practice Patterns in Extramammary Paget's Disease

JEADV Clinical Practice, EarlyView.
ABSTRACT Background In patients with Extramammary Paget's Disease (EMPD), a rare intraepithelial adenocarcinoma, wide local excision (WLE) has historically been the standard of treatment despite high rates of positive margins and recurrence. Mohs micrographic surgery (MMS) has demonstrated superior outcomes, yet practice patterns vary due to limited ...
Yasmine Mohseni, Olivia Burke, John Tsatalis, Clara Milikowski, Alyx Rosen Aigen   +4 more
wiley   +1 more source

Diffuse cranial vault hyperostosis associated with long‐term antiepileptic therapy: Autopsy findings and differential diagnostic considerations

Journal of Forensic Sciences, EarlyView.
Abstract Diffuse cranial vault hyperostosis is an uncommon finding and may present a diagnostic challenge in clinical and forensic practice. We report the case of a 53‐year‐old woman with a long‐standing history of epilepsy treated with phenytoin and sodium valproate who collapsed at home suddenly and died despite resuscitative efforts.
Maria Piagkou, Athina Tousia, George Triantafyllou, Dimitrios Vlachodimitropoulos, Samer Al Besher, Panagiotis Manolarakis‐Papadopoulos, Alexandros Samolis, Stavroula Papadodima   +7 more
wiley   +1 more source