Results 21 to 30 of about 38,371 (241)
Angewandte Chemie, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee +5 more
wiley +2 more sources
Ketamine Use for Successful Resolution of Post-ERCP Acute Pancreatitis Abdominal Pain
Case Reports in Anesthesiology, 2017 We report a case in which a patient with intractable pain secondary to post-endoscopic retrograde cholangiopancreatography (ERCP) acute pancreatitis is successfully treated with a subanesthetic ketamine infusion.
Suneel M. Agerwala +2 more
doaj +1 more source
"Semicut” skill on the cystic duct in laparoscopic cholecystectomy
Frontiers in Surgery, 2023 This study aimed to decrease the incidence of residual stones in the cystic duct and consequently decrease the incidences of intractable pain and the formation of a small gallbladder after laparoscopic cholecystectomy (LC).
Linxun Liu, Zhanxue Zhao, Jinyu Yang
doaj +1 more source
Ultrasound-Guided Nerve Block with Botulinum Toxin Type A for Intractable Neuropathic Pain
Toxins, 2016 Neuropathic pain includes postherpetic neuralgia (PHN), painful diabetic neuropathy (PDN), and trigeminal neuralgia, and so on. Although various drugs have been tried to treat neuropathic pain, the effectiveness of the drugs sometimes may be limited for ...
Young Eun Moon +4 more
doaj +1 more source
Surgery for Spine Disease and Intractable Pain
Brain Sciences, 2020 Painful conditions, particularly due to head pain, spinal disease, and neuropathic pain, are highly prevalent in modern society, resulting in a significant impact on the individual due to the disability of the condition and the direct cost of associated ...
Warren Boling
doaj +1 more source
Case Reports in Neurological Medicine, 2014 Headaches and facial pain can be extremely difficult to manage for the patient and the clinician. In the medical literature, it has been suggested that the autonomic reflex plays an important role in the pathophysiology of facial neuralgia.
Foad Elahi, Kwo Wei David Ho
doaj +1 more source
OPEN ANTERIOR CORDOTOMY AS A POSSIBLE TECHNIQUE FOR PAIN RELIEF IN CANCER PATIENT: AN EXPERIENCE WITH SEVEN CASES [PDF]
Acta Medica Iranica, 1996 Seven patients who had intractable pain of the pelvis and lower extremities were scheduled for cordotomy of the spinothalamic tracts after preliminary investigations.
Sheikhrezai +4 more
doaj +1 more source
Advanced Science, EarlyView.A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li +9 more
wiley +1 more source
Effects of an Inpatient Program on Medication Errors in Hospitalized People with Parkinson's Disease
Annals of Neurology, EarlyView.Objective Hospitalized people with Parkinson's disease (PwP) face increased risks of medication errors and discharge to non‐home settings, both of which are associated with adverse outcomes. This study assessed differences in medication error rates and discharge outcomes before and after implementation of a dedicated inpatient program for hospitalized ...
Camila C. Piccinin +15 more
wiley +1 more source