Results 121 to 130 of about 2,955,039 (285)

Brachyury‐Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment

Advanced Science, EarlyView.
This study describes the creation of injectable Brachyury (Bry) mRNA‐loaded Fucoidan‐functionalized GelMA hydrogel microspheres (BLNP@GF). These microspheres efficiently suppress inflammation, enhance extracellular matrix (ECM) synthesis in degenerated nucleus pulposus cells, and mitigate intervertebral disc degeneration (IVDD) in rat models.
Yuhao Gong, Wenxiao Shi, Xingzhu Liu, Hang Yu, Yinghui Wu, Yanzhang Xia, Caichun Yue, Chongkai Yang, Cong Shen, Renjun Pei, Tianwen Xin, Hailong Pei, Jun Shen   +12 more
wiley   +1 more source

Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy

Advanced Science, EarlyView.
Patients with osteoporosis face a higher risk of bone injury, mainly due to weakened osteogenic differentiation and bone formation, along with increased osteoclast differentiation and bone resorption activity, leading to bone homeostasis imbalance.
Xinhui Wu, Tianlong Wang, Jinhui Zhao, Lei Zhang, Zhiqing Liu, Yixing Chen, Yiping Luo, Yaqi Liu, Yan Chen, Hui Jiang, Dilixiati Duolikun, Junjian Liu, Wentao Cao, Longpo Zheng   +13 more
wiley   +1 more source

Clinical effectiveness and safety of intraoperative methadone in patients undergoing laparoscopic hysterectomy: a randomised, blinded clinical trial

BJA Open, 2023
Background: Laparoscopic hysterectomy is often carried out as day-stay surgery. Minimising postoperative pain is therefore of utmost importance to ensure timely discharge from hospital.
Kristian D. Friesgaard, Lone D. Brix, Christina B. Kristensen, Omar Rian, Lone Nikolajsen   +4 more
doaj  

Comparison of postoperative pain according to the harvesting method used in hair restorative surgery

Archives of Plastic Surgery, 2019
Background Postoperative pain is one of the most common concerns of patients undergoing hair transplantation surgery. Because most patients are satisfied with the cosmetic improvement after transplantation, amelioration of postoperative pain would help ...
Yang Seok Kim, Young Cheon Na, Jae Hyun Park   +2 more
doaj   +1 more source

HTX-011 reduced pain intensity and opioid consumption versus bupivacaine HCl in bunionectomy: phase III results from the randomized EPOCH 1 study. [PDF]

, 2019
BACKGROUND AND OBJECTIVES: There is a need for local anesthetics that provide consistent analgesia through 72 hours after surgery. This study evaluates the use of HTX-011 (bupivacaine and meloxicam in Biochronomerpolymer technology), an extended-release,
Gimbel, Joseph S., Hu, Jia, Lee, Gwo-Chin, Pollack, Richard A., Viscusi, Eugene R.   +4 more
core   +1 more source

Functionalized Biomimetic Nanoparticles Targeting the IL‐10/IL‐10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis

Advanced Science, EarlyView.
The MOF material UIO‐66‐NH2 is functionalized with DBCO groups on its surface, encapsulating NO‐prednisolone and conjugating it with azide‐modified IL‐10. Finally, the complex is extruded with MM to form biomimetic functional nanoparticles. Upon intra‐articular injection, MI@UN, enveloped by the MM, specifically targets synovial macrophages, is ...
Wenwei Li, Yang Liu, Ming Wei, Zhichao Yang, Zhaoyu Li, Zezhong Guo, Liang Yan, Yang Lu, Hao Tang, Bofeng Li, Wei Huang   +10 more
wiley   +1 more source

Wireless In Situ Catalytic Electron Signaling‐Mediated Transcriptomic Reprogramming for Neuron Regeneration via Adaptable Antennas

Advanced Science, EarlyView.
A wireless‐charging sustained oxygen release from conductive microgels (SOCO) served as an antenna and an on‐demand O2 release for nerve regeneration is developed. Introducing “electromagnetic messenger”, using external alternating magnetic field (AMF) to enhance catalytic oxygen release and electrical stimulation to promote the reconstruction of blood
Hoi Man Iao, Chih‐Ying Chen, Ya‐Hui Lin, Wan‐Chi Pan, Chun‐Yi Liang, Hsiu‐Ching Liu, Lo‐Jei Ching, Pei‐Yu Weng, Min‐Ren Chiang, Ru‐Siou Hsu, Tsu‐Chin Chou, I‐Chi Lee, Lun‐De Liao, Li‐An Chu, Shih‐Hwa Chiou, Shang‐Hsiu Hu   +15 more
wiley   +1 more source

PROCEEDINGS OF CURED AND CRHONIC CONFERENCE - INTRODUCTION

Journal of Cancer Rehabilitation
The IX European Conference Cured & Chronic, held in Siracusa (Italy) on October 23, 2024, has entrusted distinguished worldwide speakers with the task of focusing on the main issues that arise during and beyond the cancer journey.
Vittorio Mattioli
doaj  

The Relationship of Postoperative Pain and Opioid Consumption to Postoperative Delirium After Spine Surgery

Journal of Pain Research, 2023
Ryan Sica,1 Jenna M Wilson,1 Erin J Kim,1 Deborah J Culley,1,2 Samantha M Meints,1 Kristin L Schreiber1 1Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 2Department of
Sica R, Wilson JM, Kim EJ, Culley DJ, Meints SM, Schreiber KL   +5 more
doaj  

Utilization of a multimodal preoperative pain regimen prior to gynecologic oncology exploratory laparotomies [PDF]

, 2017
Objective: The aim of this study was to evaluate the use of a combination of non-opioid preoperative pain medications including Tylenol, Lyrica, and Celecoxib (TLC) in patients undergoing gynecologic oncologic exploratory laparotomies.
Hand, MD, Lauren C., Kim, MD, Christine H., Maas, MD, Talia, Masi, MD, Kristina, Mercier MD MPH, Rebecca J., Rosenblum, MD, PhD, Norman G., Vogell, MD, Alison   +6 more
core   +1 more source