Results 101 to 110 of about 1,797,741 (304)

Poorly controlled postoperative pain: prevalence, consequences, and prevention

, 2017
Tong J Gan Stony Brook University, Stony Brook, NY, USA Abstract: This review provides an overview of the clinical issue of poorly controlled postoperative pain and therapeutic approaches that may help to address this common unresolved health-care ...
Gan TJ
core  

Liquid‐Responsive Shape‐Memory Nanofiber‐Reinforced Scaffolds for Cartilage Repair

Advanced Science, EarlyView.
A liquid‐responsive shape‐memory, nanofiber‐reinforced QCG scaffold combines conformal defect filling, an aligned architecture that is structurally permissive for endogenous cell infiltration, and sustained KGN release. This integrated design enhances BMSC viability, migratory activity, and chondrogenic differentiation and promotes hyaline cartilage ...
Jiyang Zeng, Wei Li, Yawei Li, Zhiming Tu, Hong Ma, Yuliang Dai, Zhaoling Ma, Tao Yuan, Bing Wang   +8 more
wiley   +1 more source

Why Postoperative Pain Remains a Problem

, 2015
Despite great progress in our understanding and management of pain, undertreatment of postoperative pain is still a major problem. There are individual patient differences in terms of nociception and perception, as well as varying responses to pain ...
Lundborg, Christopher,
core   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

PROCEEDINGS OF CURED AND CRHONIC CONFERENCE - INTRODUCTION

Journal of Cancer Rehabilitation
The IX European Conference Cured & Chronic, held in Siracusa (Italy) on October 23, 2024, has entrusted distinguished worldwide speakers with the task of focusing on the main issues that arise during and beyond the cancer journey.
Vittorio Mattioli
doaj  

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Efficacy and Clinical Utility of Pectoral Nerve Blocks in Thoracic Surgery

Southeastern European Medical Journal
Postoperative pain remains a major challenge after thoracic surgery, including video-assisted thoracoscopic surgery (VATS). Although thoracic epidural analgesia (TEA) and thoracic paravertebral block (TPVB) are established components of multimodal ...
Sven Katalinić, Ivana Haršanji Drenjančević, Hrvoje Vinković, Dino Budrovac, Sonja Škiljić, Gordana Kristek   +5 more
doaj   +1 more source

Preventive analgesia for postoperative pain control: a broader concept

, 2014
Nalini Vadivelu,1 Sukanya Mitra,2 Erika Schermer,3 Vijay Kodumudi,4 Alan David Kaye,5 Richard D Urman61Department of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA; 2Department of Anesthesia and Intensive Care, Government Medical ...
Kaye AD, Schermer E, Kodumudi V, Urman RD, Vadivelu N, Mitra S   +5 more
core  

Prediction of Postoperative Pain from Electrical Pain Thresholds after Laparoscopic Cholecystectomy

, 2017
OBJECTIVE:: Early postoperative pain correlates to persisting pain, psychosocial distress, and delayed mobilization with thromboembolic and infectious complications.
Jonas Åkeson, Anna K.M. Persson, Dyrehag, L-E, Åkeson, Jonas, Persson, Anna K M, Lars-Erik Dyrehag, Dyrehag, L-E,, Persson, Anna K M,, Åkeson, Jonas,, Lund University.   +9 more
core   +1 more source

Longitudinal Awake Mouse Brain Imaging Using Functional Ultrasound and Functional Ultrasound Localization Microscopy

Advanced Science, EarlyView.
Awake longitudinal multimodal ultrasound imaging integrates functional ultrasound (fUS), ultrasound localization microscopy (ULM), and functional ULM (fULM) to characterize cerebrovascular function, microvascular architecture, and flow dynamics within the same animals over time.
Zhe Huang, Yike Wang, Matthew R. Lowerison, Yue Xu, Murong Yi, Bing‐Ze Lin, YiRang Shin, Nathiya Vaithiyalingam Chandra Sekaran, Daniel A. Llano, Pengfei Song   +9 more
wiley   +1 more source