Results 91 to 100 of about 1,697,378 (293)

From labor to surgery: expanding the role of programmed intermittent epidural bolus beyond obstetric [PDF]

open access: yesAnesthesia and Pain Medicine
Epidural analgesia has been effective for postoperative pain control, but its use has declined owing to adverse effects, such as motor blockade and delayed recovery.
Yu Jeong Bang, RyungA Kang
doaj   +1 more source

Phantom pain [PDF]

open access: yes, 2016
Almost anyone with a limb amputation experiences phantom sensations. Moreover, the majority of amputees experience pain. This phenomenon is known as ‘Phantom pain’ and is described as the pain felt from a body part, usually a limb, which is no longer ...
Duca, Kristina, Muscat, Richard
core  

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

open access: yesAdvanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang   +7 more
wiley   +1 more source

Perioperative cognitive behavioural therapy compared with pain education and mindfulness for chronic postsurgical pain in breast cancer patients with high pain catastrophising characteristics: a randomised, controlled, parallel group clinical trial

open access: yesBJA Open
Background: The incidence of chronic postsurgical pain (CPSP) is relatively high after breast cancer surgery. Psychological factors, especially high pain catastrophising, are predictive of CPSP.
Aneurin Moorthy   +5 more
doaj   +1 more source

Efficacy of pectoral nerve II block for flap dissection-related pain following robot-assisted transaxillary thyroidectomy: a prospective, randomized controlled trial [PDF]

open access: yesKorean Journal of Anesthesiology
Background Robot-assisted transaxillary thyroidectomy (RATT) involves extensive flap dissection, leading to significant postoperative pain. This study evaluated the efficacy of pectoral nerve II (PECS II) block in pain relief, opioid reduction, and ...
Min Suk Chae, Kwangsoon Kim
doaj   +1 more source

NEFOPAM IN POSTOPERATIVE PAIN

open access: yesBritish Journal of Anaesthesia, 1979
Three comparable groups of surgical patients were given nefopam 0.2 mg kg-1 or 0.4 mg kg-1 or morphine 0.15 mg kg-1 for pain relief after operation. Nefopam 0.4 mg kg-1 was equi-analgesic with morphine 0.15 mg kg-1 and produced no obvious cardiovascular or respiratory side-effects.
G, Phillips, M D, Vickers
openaire   +2 more sources

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

open access: yesAdvanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan   +10 more
wiley   +1 more source

Comparison of the effects of indomethacin, diclofenac and acetaminophen suppositories on pain score and pethedine usage after cesarean section [PDF]

open access: yes
Background : Cesarean section is one of the common surgeries of women. The rate of cesarean section over the west societies is currently about 14%-15%. In Iran the rate of cesarean section is higher than universal statistics. Acute postoperative pain is
اخوان اکبری, قدرت   +2 more
core  

Patient experiences of anxiety, depression and acute pain after surgery: a longitudinal perspective [PDF]

open access: yes, 2005
This study sought to explore the impact of the psychological variables anxiety and depression, on pain experience over time following surgery. Eighty-five women having major gynaecological surgery were assessed for anxiety, depression and pain after ...
Thomas, Veronica Nicky   +5 more
core   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

open access: yesAdvanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong   +17 more
wiley   +1 more source

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