Results 71 to 80 of about 1,797,741 (304)

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Descritores de dor pós-hemorroidectomia Descriptores de dolor post-hemorroidectomia Post-hemorrhoidectomy pain descriptors

Revista Latino-Americana de Enfermagem, 2005
Estudo conduzido com o objetivo de comparar as escalas derivadas de julgamentos de diferenças e verificar a estabilidade e a concordância das estimativas da atribuição dos descritores à dor pós-operatória julgadas por três diferentes amostras ...
Hortense Priscilla, Renata Alessandra Evangelista, Fátima Aparecida Emm Faleiros Sousa   +2 more
doaj   +1 more source

Management of postoperative pain in Spain: a nationwide survey of practice

, 2017
BACKGROUND: Although the need for structured assessment and management of acute postoperative pain has been recognized, practices and responsibilities vary between and within hospitals and countries.
F. Caba, M. C. Benito, Montes Pérez, Antonio, Margarit, Cesar, null null, Aguilar, José, Caba, Fernando, C. Margarit, J. L. Aguilar, A. Montes, Acute Pain Group of the Spanish Pain Society (SED), Benito, M C, Montes, A, Caba, F, Benito, María del Carmen, Margarit, C, Aguilar, J L   +16 more
core   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Effective protocol for continuous pericapsular nerve group block in femur fracture patients undergoing hip surgery: two case reports [PDF]

Kosin Medical Journal
Pericapsular nerve group (PENG) block was introduced as an effective way to control postoperative pain in patients who have undergone hip surgery. Therefore, we would like to discuss how to perform PENG block accurately on the basis of two cases, both of
Younghoon Jung, Sangmin Choi, Siyoung Lee, Nara Kim, Eunsoo Kim   +4 more
doaj   +1 more source

"A pain that ruins mountains" : a case study of factors influencing postoperative pain management in two Jordanian hospitals [PDF]

Postoperative pain is still poorly managed among surgical patients despite evidence-based approaches to its treatment being well established. Prompted by the persistence of this problem, many researchers have studied factors influencing postoperative ...
Daibes, Mayada
core  

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Transcranial Color Doppler for Assessing Cerebral Venous Outflow in Critically Ill and Surgical Patients

Diagnostics
In recent years, Transcranial Color Doppler (TCCD) has gained increasing recognition as a non-invasive neuromonitoring tool. However, there remains a strong tendency to view arterial TCCD as the ‘stethoscope for the brain,’ while the assessment of ...
Amedeo Bianchini, Giovanni Vitale, Gabriele Melegari, Matteo Cescon, Matteo Ravaioli, Elena Zangheri, Maria Francesca Scuppa, Stefano Tigano, Antonio Siniscalchi   +8 more
doaj   +1 more source

Costoclavicular block as a diaphragm-sparing nerve block for shoulder surgery: a randomized controlled trial [PDF]

Korean Journal of Anesthesiology
Background Distal nerve block approaches have been explored to reduce hemidiaphragmatic paresis (HDP) more effectively than interscalene block (ISB). However, these approaches are associated with a high incidence of HDP.
Youngin Lee, Seunguk Bang, Jihyun Chung, Min Suk Chae, Jungwon Shin   +4 more
doaj   +1 more source

Pain is what the patient says it is, but… : an ethnographic study of the factors which influence nurses when they make pain management decisions in a clinical setting [PDF]

Barriers to effective postoperative pain management mean many patients suffer needless pain. Few studies have observed nurses as they manage postoperative pain in a clinical setting; those who used observation have demonstrated the importance of ...
van Raders, Petronella
core