Results 41 to 50 of about 1,697,378 (293)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Thermoresponsive Soft and Self‐Anchoring Cuff Electrode for Chronic Peripheral Interfaces

Advanced Functional Materials, EarlyView.
A novel thermoresponsive, soft and self‐anchoring (TSSA) cuff electrode utilizing shape memory polymers achieves autonomous, sutureless peripheral nerve fixation. Driven by thermally induced pre‐strain and tissue adhesion, the device self‐closes and softens at body temperature, successfully minimizing mechanical mismatch. This adaptive platform ensures
Seungjun Lee, Byungwook Park, Jonghee Eun, Sohee Kim, Namsun Chou   +4 more
wiley   +1 more source

Caesarean delivery: Bringing more than just a bundle of joy

Canadian Journal of Pain, 2019
Background: Chronic postsurgical pain (CPSP) is a potential complication of all surgical procedures, including caesarean delivery (CD). Psychological factors such as anxiety and depression with negative coping strategies are known to increase the risk of
Jane Quinlan
doaj   +1 more source

Psychophysical evaluation of the descriptors of pain in the postoperative Evaluación psicofísica de los descriptores de dolor en el post-operatorio Avaliação psicofísica de descritores de dor no pós-operatório

Revista Latino-Americana de Enfermagem, 2007
This experimental study aimed to evaluate 20 descriptors of the post-operative pain considering the adequate level of each in describing it. A total of 48 post-operated patients, age between 14 and 70 years old, 60.4% male, participated in the experiment.
Lilian Varanda Pereira, Fátima Aparecida Emm Faleiros Sousa   +1 more
doaj   +1 more source

The effects of indomethacin, diclofenac, and acetaminophen suppository on pain and opioids consumption after cesarean section [PDF]

Background: Cesarean section is one of the common surgeries of women. Acute post-operative pain is one of the recognized post-operative complications.
Masood Entezariasl, Fariba Kahnamoyiagdam, اخوان اکبری, قدرت, عیسی زاده فر, خاطره, انتظاری, مسعود, Godrat Akhavanakbari, Khatereh Isazadehfar, کهنمویی, فریبا   +7 more
core   +1 more source

Realistic goals can help manage children’s post-operative pain effectively [PDF]

, 2014
Effective pain management should be a fundamental right of the child (United Nations 1989) and nurses are best placed to facilitate this (Lim et al 2011). Improving pain management for children has been debated and explored in past decades.
Vasey, Jackie
core   +1 more source

Postoperative Pain Is Driven by Preoperative Pain, Not by Endometriosis [PDF]

, 2021
(1) Background: The aim of this study was to evaluate the impact of endometriosis on postoperative pain following laparoscopic hysterectomy; (2) Methods: A total of 214 women who underwent a laparoscopic hysterectomy between January 2013 and October 2017
Kanellos, Panagiotis, Sara Imboden, Michael D. Mueller, Panagiotis Kanellos, Franziska Siegenthaler, Konstantinos Nirgianakis, Siegenthaler, Franziska, Nirgianakis, Konstantinos, Vetter, Christian, Imboden, Sara, Mueller, Michael D., Christian Vetter   +11 more
core   +2 more sources

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

Modified approach to external oblique intercostal block: a proof-of-concept pilot case series and anatomical evaluation -a case series- [PDF]

Korean Journal of Anesthesiology
Background Regional anesthesia techniques that provide analgesia to the entire lateral abdomen are limited. We present a modified external oblique intercostal block for complete lateral abdominal analgesia with a single injection.
Takashi Fujino, Koichiro Ichimura, Hidaka Anetai, Izumi Kawagoe   +3 more
doaj   +1 more source

Preoperative Risk Factors for Opioid Use Predict Self-Reported Health and Function Up to 6 Months After Anterior Cruciate Ligament Reconstruction. [PDF]

Arthrosc Sports Med Rehabil
Purpose To identify risk factors that predict the need for rescue opioid use and patient‐reported outcomes following an opioid‐limiting postoperative analgesia protocol after anterior cruciate ligament reconstruction. Methods This prospective cohort study recruited 44 patients undergoing primary arthroscopic‐assisted anterior cruciate ligament ...
Neufeld EV, DeGouveia W, Pinpin C, Zinner M, Sayegh MJ, Meade MJ, Rokito SE.   +6 more
europepmc   +2 more sources