Results 51 to 60 of about 10,800,546 (271)

Neurocognitive, School‐Based, and Quality of Life Outcomes for Youth With Sickle Cell Disease and Thalassemia: A Scoping Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling, Hakim Tokhi, Alexander A. Boucher   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Relation Between Pain-Related Fear and Disability: A Meta-Analysis [PDF]

The Journal of Pain, 2013
Within a biopsychosocial framework, psychological factors are thought to play an important role in the onset and progression of chronic pain. The cognitive-behavioral fear-avoidance model of chronic pain suggests that pain-related fear contributes to the development and maintenance of pain-related disability.
Emily L, Zale, Krista L, Lange, Sherecce A, Fields, Joseph W, Ditre   +3 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Pain catastrophizing, pain sensitivity and fear of pain are associated with early life environmental unpredictability: a path model approach

BMC Psychology, 2022
Background Socioeconomic disadvantages in the childhood environment might strongly influence beliefs and behavior characterizing the adult years. When children experience unpredictable and adverse situations, they develop an unpredictability schema with ...
Eszter Simon, András N. Zsidó, Béla Birkás, Árpád Csathó   +3 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Words putting pain in motion: The generalization of pain-related fear within an artificial stimulus category

Frontiers in Psychology, 2015
Patients with chronic pain are often fearful of movements that never featured in painful episodes. This study examined whether a neutral movement’s conceptual relationship with pain-relevant stimuli could precipitate pain-related fear; a process known as
Marc Patrick Bennett, Marc Patrick Bennett, Ann eMeulders, Ann eMeulders, Frank eBaeyens, Frank eBaeyens, Johan W Vlaeyen, Johan W Vlaeyen, Johan W Vlaeyen   +8 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

The Fear of Movement/Pain in Musculoskeletal Pain-A Review

Journal of Rehabilitation, 2012
Objective: To investigate and review psychological influences of pain such as kinesiophobia and pain-related fear on patients with musculoskeletal pain and on rehabilitation outcomes. Materials & Methods: Fear is a universal and powerful emotion and, as
Behnam Akhbari, Sharzad Mohammadi-Raad, Mahyar Salavati   +2 more
doaj  

Indirect acquisition of pain-related fear: an experimental study of observational learning using coloured cold metal bars.

PLoS ONE, 2015
BackgroundPrevious research has demonstrated that pain-related fear can be acquired through observation of another's pain behaviour during an encounter with a painful stimulus. The results of two experimental studies were presented, each with a different
Kim Helsen, Johan W S Vlaeyen, Liesbet Goubert   +2 more
doaj   +1 more source