Results 111 to 120 of about 2,787,217 (313)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Edwin Mervyn Pain [PDF]

open access: yes, 2007
"VX 137167 Edwin Mervyn Pain 38th Aust Inf Battalion 1943 - 1944".VX 137167 Edwin Mervyn Pain 38th Australian Infantry Battalion 1943 ...
Pain, Edwin Mervyn
core  

Pain and the ethics of pain management [PDF]

open access: yesSocial Science & Medicine, 1984
In this article I clarify the concepts of 'pain', 'suffering', 'pains of body', 'pains of soul'. I explore the relevance of an ethic to the clinical setting which gives patients a strong prima facie right to freedom from unnecessary and unwanted pain and which places upon medical professionals two concomitant moral obligations to patients. First, there
openaire   +2 more sources

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

open access: yesFEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow   +12 more
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

open access: yesAging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho   +4 more
wiley   +1 more source

Caregiver Pain Medicine Questionnaire (CPMQ). [PDF]

open access: yes, 2004
The CPMQ is a 22-item self-report instrument. Each item is scored on a five-point Likert scale of agreement ((1 = strongly disagree; 5 = strongly agree). Higher number indicates a high level of agreement and greater concern about managing pain issues.The
Marijo Letizia, Steve Creech, Ellen Norton, Marie Shanahan,Lori Hedges.
core  

Perspectivas de la Sociología en los Países Africanos de Lengua Oficial Portuguesa

open access: yesUniversitas
La presente investigación analiza algunos de los desafíos enfrentados por los Países Africanos de Lengua Oficial Portuguesa (PALOPs) en la consolidación de la Sociología como un área de conocimiento relevante, tanto en el ámbito universitario como ...
Rodrigo de Souza-Pain
doaj   +1 more source

Profound Leadership Strategies: Transcending the Leadership Crisis in the Age of Artificial Intelligence

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article examines the evolving role of organizational leadership amidst the rapid advancements in artificial intelligence (AI). It explores a broadly experienced and documented crisis in leadership, due in part to the disruptive nature of AI and emerging technology.
Rachel Wlodarsky, Davin Carr Chellman
wiley   +1 more source

Parental concern and distress about infant pain [PDF]

open access: yes, 2004
Objective: To describe parent views on infant pain care and to explore relations between parents’ experience of their infant’s pain care and parental stress. Design: Descriptive, cross sectional survey.
Winter, I   +7 more
core  

Evaluating the Interaction between Pain Intensity and Resilience on the Impact of Pain in the Lives of People with Fibromyalgia [PDF]

open access: yes
Objective: Recent theoretical models posit that resilience acts as a resource/mechanism opposing pain catastrophizing and other vulnerability sources against pain adaptation.
Barros, Guilherme Antonio Moreira De [UNESP]   +8 more
core   +2 more sources

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