Results 101 to 110 of about 2,787,217 (313)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations [PDF]

, 2015
There is growing concern about lack of scientific rigor and transparent reporting across many preclinical fields of biological research. Poor experimental design and lack of transparent reporting can result in conscious or unconscious experimental bias ...
Lee, N, Svensson, CI, Levine, J, Jensen, MP, Mogil, JS, Stone, L, McMahon, SB, Gover, TD, Turk, DC, Evans, S, Gewandter, JS, Handwerker, H, Basbaum, AI, Ross, SE, Currie, GL, Iyengar, S, Andrews, NA, McDermott, MP, Latrémolière, A, Huang, W, Porreca, F, Seal, RP, Sena, ES, Eisenach, JC, Kennedy, JD, Lidster, K, Machin, I, Silva, E, Woolf, CJ, Price, TJ, Scherrer, G, Whiteside, G, Dworkin, RH, Rice, AS   +33 more
core   +1 more source

O desafio e as perspectivas da Sociologia nos Países Africanos de Língua Oficial Portuguesa (PALOP)

Revista Sítio Novo
O presente trabalho aponta para alguns dos desafios enfrentados pelos Países Africanos de Língua Oficial Portuguesa (PALOP) na consolidação da Sociologia como área relevante do conhecimento, seja no âmbito universitário ou escolar.
Rodrigo de Souza Pain
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Os desafios e perspectivas da Sociologia nos Países Africanos de Língua Oficial Portuguesa (PALOPs)

Intellèctus
O presente trabalho aponta para alguns dos desafios enfrentados pelos Países Africanos de Língua Oficial Portuguesa (PALOPS) na consolidação da Sociologia como área do conhecimento relevante, seja no âmbito universitário ou escolar.
Rodrigo de Souza Pain
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Pain relief is associated with decreasing postural sway in patients with non-specific low back pain [PDF]

, 2012
Background Increased postural sway is well documented in patients suffering from non-specific low back pain, whereby a linear relationship between higher pain intensities and increasing postural sway has been described.
Walker Bruce, Ruhe Alexander, Alexander Ruhe, Ruhe, A., Bruce Walker, Walker, B., Fejer, R., Fejer René, René Fejer, Fejer, René   +9 more
core   +2 more sources

PAIN [PDF]

Brain, 1902
n ...
openaire   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

The President Is in: Public Opinion and the Presidential Use of Twitter

Social Media + Society, 2019
Analyzing President Trump’s Tweets ( N  = 30,386) with the first tweet starting from 4 May 2009, this article looks at the nature of his conversations with the public and the building of public support for his candidacy, till he assumed office on January
Paromita Pain, Gina Masullo Chen
doaj   +1 more source