Results 61 to 70 of about 4,741,499 (307)

Goal pursuit in individuals with chronic pain: a personal project analysis [PDF]

, 2016
Objectives: In individuals with chronic pain (ICPs), controlling pain often is a salient goal, despite the difficulty to achieve it. This situation may bring along frustration and distress.
Crombez, Geert, Goubert, Liesbet, Lauwerier, Emelien, Van Damme, Stefaan   +3 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Heritability of pain catastrophizing and associations with experimental pain outcomes: a twin study [PDF]

, 2015
This study used a twin paradigm to examine genetic and environmental contributions to pain catastrophizing and the observed association between pain Catastrophizing and cold-pressor task (CPT) outcomes. Male and female monozygotic (n = 206) and dizygotic
Afari, Afari, Angst, Belfer, Boomsma, Busjahn, Crombez, Diatchenko, Finan, Gatchel, George, Goubert, Goubert, Horsham, Hur, Jensen, Karsdorp, Kato, Keefe, Kendler, Kozak, Kraljevic, Leeuw, McGue, Mogil, Nielsen, Norbury, Osman, Pavlakovic, Quartana, Rijsdijk, Seminowicz, Smeets, Stein, Strachan, Sullivan, Sullivan, Sullivan, Sullivan, Sullivan, Sullivan, Trost, Trost, Turk, Turner, Van Damme, Van Damme, Van Damme, Vassend, Verhoeven, Vervoort, Vervoort, Vervoort, Weissman-Fogel, Wilson   +54 more
core   +2 more sources

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Multicenter assessment of quantitative sensory testing (QST) for the detection of neuropathic-like pain responses using the topical capsaicin model [PDF]

, 2018
Background: The use of quantitative sensory testing (QST) in multicenter studies has been quite limited, due in part to lack of standardized procedures among centers. Aim: The aim of this study was to assess the application of the capsaicin pain model
Bushnell, M. Catherine, Chouchou, Florian, Ferland, Catherine E., Gandhi, Wiebke, Jackson, Philip L., Lavigne, Gilles, Ma, My-Linh, Marchand, Serge, Michon, Pierre-Emmanuel, Parent, Alexandre J., Rainville, Pierre, Schweinhardt, Petra, Villemure, Chantal, Ware, Mark A.   +13 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Extracting Physical Information from the Voigt Profile Using the Lambert W Function

Plasma
Spectral line shapes are a key ingredient of hot-plasma opacity calculations. Since resorting to elaborate line-shape models remains prohibitive for intensive opacity calculations involving ions in different excitation states, with L, M, etc., shells are
Jean-Christophe Pain
doaj   +1 more source

A nationwide study of chronic pain prevalence in the general Spanish population, identifying clinical subgroups through cluster analysis. [PDF]

, 2015
Objective. This study aims to assess the prevalence of chronic pain, its characteristics, and its impact on the general Spanish population. Also, to establish chronic pain patient subgroups according to the characteristics of pain and to identify ...
Dueñas Rodríguez, María Ángeles, Failde Martínez, Inmaculada, Fernández Palacín, Fernando, Micó Segura, Juan Antonio, Ojeda, Begoña, Salazar Couso, Alejandro, Torres, Luis Miguel   +6 more
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source