Results 51 to 60 of about 6,329,531 (295)

"I feel so stupid because I can't give a proper answer ..." How older adults describe chronic pain: a qualitative study [PDF]

, 2012
Background - Over 50% of older adults experience chronic pain. Poorly managed pain threatens independent functioning, limits social activities and detrimentally affects emotional wellbeing.
Clarke, Amanda, McNamee Paul, Anthony, Geraldine, Paul McNamee, Geraldine Anthony, Blair H Smith, Schofield Patricia, Martin Denis, Denise Gray, Martin, D., McNamee, P., Patricia Schofield, Amanda Clarke, Gray, D., Smith Blair H, Schofield, Patricia, Smith, Blair H; id_orcid, Smith, Blair H., Derek Jones, Jones Derek, Smith, B.H., McNamee, Paul, Clarke Amanda, Anthony Geraldine, Martin, Denis, Denis Martin, Martin, Denis; id_orcid, Jones, D., Gray, Denise, Anthony, G., Jones, Derek, Gray Denise, Smith, Blair, Clarke, A.   +33 more
core   +2 more sources

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A narrative review on canine chronic pain: neurobiological insights and assessment methods to establish quality of life

Frontiers in Animal Science
Chronic or maladaptive pain is a frequent condition in canine patients that causes alterations due to the persistent sensitization of pain receptors.
Ismael Hernández-Avalos, Julio Martínez-Burnes, Patricia Mora-Medina, Adriana Olmos-Hernández, Karina Lezama-García, Adriana Domínguez-Oliva, Agatha Miranda-Cortes, Alejandro Casas-Alvarado, Daniel Mota-Rojas   +8 more
doaj   +1 more source

Psychometric evaluation of the electronic faces thermometer scale for pain assessment in children 8–17 years old: A study protocol

Paediatric & Neonatal Pain, 2023
It is often a challenge for a child to communicate their pain, and their possibilities to do so should be strengthened in healthcare settings. Digital self‐assessment provides a potential solution for person‐centered care in pain management and promotes ...
C. Castor, M. Björk, J. Bai, H. Berlin, G. Kristjansdottir, O. Kristjansdottir, H. Hansson, A. Höök, P. Stenström, S. Nilsson   +9 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Assessment of chronic postsurgical pain after knee replacement : a systematic review [PDF]

, 2013
Objective: Approximately 20% of patients experience chronic pain after total knee replacement (TKR), yet there is no consensus about how best to assess such pain.
Rachael Gooberman‐Hill, Karen Elvers, Vikki Wylde, Wylde, Vikki, Beswick, Andrew, Elvers, Karen, Julie Bruce, Gooberman-Hill, Rachael, Bruce, Julie, Andrew Beswick, Bruce, J. (Julie)   +10 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Clinical value of chest pain presentation and prodromes on the assessment of cardiovascular disease: a cohort study. [PDF]

, 2015
OBJECTIVES: The recognition of coronary artery disease (CAD) among patients who report chest pain remains difficult in primary care. This study investigates the association between chest pain (specified, unspecified or musculoskeletal) and prodromes ...
Robson, J, Addo, J, Wragg, A, Mathur, R, Ayerbe, L, Mathur, Rohini, Ayerbe, Luis, Wragg, Andrew, Robson, John, Addo, Juliet   +9 more
core   +1 more source

Conservative management of low back pain [PDF]

, 2001
Back pain is prevalent worldwide, but back pain disability has reached epidemic proportions in many industrialised societies. Few patients have serious medical pathology or direct neurological involvement requiring surgery.
Frank, AO, De Souza, LH
core   +3 more sources