Results 61 to 70 of about 6,329,531 (295)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Pain management following new and long-standing spinal cord injury: A pilot study of changes in pain intensity experienced during the day [PDF]

open access: yes, 2013
The aim of the study was to examine variations in pain intensity during the day experienced by patients with spinal cord injury. Fourteen consecutive patients had clinical and demographic data recorded.
Frank, AO   +3 more
core   +1 more source

A novel virtual reality-based educational module to address gaps in morphine titration training among medical students

open access: yesBMC Medical Education
Introduction Effective intravenous morphine titration is critical for managing severe pain, particularly during the ongoing opioid crisis. However, current medical curricula often lack adequate practical training in this area.
Laura Limonta, Valeria Martinez
doaj   +1 more source

Burrowing behavior as an indicator of post-laparotomy pain in mice

open access: yesFrontiers in Behavioral Neuroscience, 2010
Detection of persistent pain of a mild-to-moderate degree in laboratory mice is difficult because mice do not show unambiguous symptoms of pain or suffering using standard methods of short-term observational or clinical monitoring.
Paulin Jirkof   +6 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Analgesic management of an eight-year-old Springer Spaniel after amputation of a thoracic limb

open access: yesIrish Veterinary Journal, 2009
Analgesic agents were administered perioperatively to an eight-year-old Springer Spaniel undergoing amputation of its right thoracic limb. The amputation was carried out due to a painful, infiltrative and poorly differentiated sarcoma involving the ...
West E   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Neuropathic pain component and its association with time elapsed since pain onset in patients with low back pain

open access: yes, 2023
Background: Time elapsed since pain onset might affect the likelihood of neuropathic component in low back pain. The aim of this study was to investigate the relationship between neuropathic pain component and pain duration in patients with low back pain
김희정   +3 more
core   +1 more source

Exploring Observational Pain Assessment Tools for Individuals with Moderate-to-Severe Dementia [PDF]

open access: yes, 2020
The global increase in the prevalence of dementia has provoked a multidisciplinary response from researchers, policymakers, educators and clinical sectors.
Babicova, I.
core   +1 more source

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