Results 31 to 40 of about 8,066 (214)
Congenital Insensibility to Pain
Medisur, 2023 Congenital insensitivity to pain is a condition that is present at birth, the affected individual is unable to perceive physical pain. The main symptoms include: wounds, bruises, fractures, self-mutilations, which can go unnoticed due to lack of ...
Carlos Gustavo López Barrionuevo +2 more
doaj
Linkage between increased nociception and olfaction via a SCN9A haplotype [PDF]
, 2013 Background and Aims: Mutations reducing the function of Nav1.7 sodium channels entail diminished pain perception and olfactory acuity, suggesting a link between nociception and olfaction at ion channel level.
Doehring, Alexandra +4 more
core +2 more sources
A Case Report of Congenital Insensitivity to Pain with Anhidrosis
罕见病研究, 2023 Congenital insensitivity to pain with anhidrosis (CIPA) is associated with Charcot arthropathy and is a rare clinical syndrome, with limited treatment options.
JIAO Yuhao, TIAN Ye, CAI Siyi
doaj +1 more source
A novel disorder reveals clathrin heavy chain-22 is essential for human pain and touch development [PDF]
, 2015 Congenital inability to feel pain is very rare but the identification of causative genes has yielded significant insights into pain pathways and also novel targets for pain treatment.
Al-Gazali, Lihadh +12 more
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Norrbottnian congenital insensitivity to pain
Acta Orthopaedica, 2006 Congenital insensitivity to pain is a rare hereditary neuropathy. We present patients from a large family in Norrbotten, Sweden with a mutation in the nerve growth factor beta gene (NGFbeta). Using a model of recessive inheritance, we identified an 8.3-Mb region on chromosome 1p11.2-p13.2 shared by the affected individuals in the family.
openaire +4 more sources
The “pain matrix” in pain-free individuals [PDF]
, 2016 Human functional imaging provides a correlative picture of brain activity during pain. A particular set of central nervous system structures (eg, the anterior cingulate cortex, thalamus, and insula) consistently respond to transient nociceptive stimuli ...
Iannetti, Gian Domenico +3 more
core +1 more source
Congenital insensitivity to pain and anhidrosis: A case report from South India
Indian Journal of Dermatology, 2012 Congenital insensitivity to pain with anhidrosis, also known as hereditary sensory and autonomic neuropathy type IV, is an autosomal recessive disorder characterized by the congenital lack of pain sensation, inability to sweat, episodes of recurrent ...
Carounanidy Udayashankar +2 more
doaj +1 more source
Eosinophilic ulcer of the tongue - Case report. [PDF]
, 2015 Eosinophilic ulcer of the oral mucosa is a rare, self-limiting, chronic and benign lesion of unknown pathogenesis that affects the oral mucosa. We present the case of a 65 year-old Caucasian female with a fivemonth history of a painful ulcer on the ...
Calvieri, Stefano +4 more
core +2 more sources
Joint Attention, Union with God, and the Dark Night of the Soul [PDF]
, 2013 Eleonore Stump has argued that the fulfilment of union between God and human beings requires a mode of relatedness that can be compared to joint attention, a phenomenon studied in contemporary experimental psychology.
Bungum, Donald
core +1 more source
Nature Communications, 2020 Loss of function of Nav1.7 leads to congenital insensitivity to pain in humans. Here the authors found that activation of Nav1.9 can restore nociception in Nav1.7 knockout mice, revealed by a venom-derived peptide as a probe.
Xi Zhou +14 more
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