Results 51 to 60 of about 8,066 (214)

Ocular manifestations of analgesia syndrom in children

Российский офтальмологический журнал, 2018
Congenital analgesia is characterized by insensitivity to pain. Children with this syndrome feel no physical pain when biting their tongues, lips, cheeks or fingers, which often results in significant bleeding.
L. S. Khamraeva, L. Yu. Bobokha
doaj   +1 more source

Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation

Cell Reports, 2021
Summary: Prdm12 is a key transcription factor in nociceptor neurogenesis. Mutations of Prdm12 cause congenital insensitivity to pain (CIP) from failure of nociceptor development.
Mark A. Landy, Megan Goyal, Katherine M. Casey, Chen Liu, Helen C. Lai   +4 more
doaj   +1 more source

Congenital insensitivity to pain and anhidrosis

Indian Journal of Orthopaedics, 2011
Congenital insensitivity to pain and anhidrosis (CIPA) is a rare reported entity characterised by disturbance in the pain and temperature perception due to involvement of the autonomic and sensory nervous system. It is an autosomal recessive trait with several defects of the gene NTRK1 coding for the neurotrophic tyrosine kinase - a nerve growth factor
Sasnur, Ashok H, Sasnur, Prakash A, Ghaus-ul, Raza Shamikh Muneer   +2 more
openaire   +3 more sources

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain [PDF]

, 2016
Loss-of-function mutations of NaV1.7 lead to congenital insensitivity to pain, a rare condition resulting in individuals who are otherwise normal except for the inability to sense pain, making pharmacological inhibition of NaV1.7 a promising therapeutic ...
Alewood, P., Dekan, Z., Deuis, J., Durek, T., Hoffmann, T., Lewis, R., Nassar, M., Sousa, S., Vetter, I., Weidner, C., Wingerd, J., Winter, Z., Zimmermann, K.   +12 more
core   +2 more sources

Educating Radiologists About Pain [PDF]

, 2016
It is vital that radiologists understand pain. After all, it is the most common symptom that leads patients to seek medical care, and represents one of the most common indications for diagnostic and interventional radiological procedures 1, 2 and 3.
Fogler, Brian D., Gunderman, Richard B.
core   +1 more source

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

MedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang, Zijiao Tian, Zhaoquan Wang, Zerui Yang, Ziyao Wang, Zikang Wang, Ziqing Wang, Xingyuan He, Yu Yan, Yuanfeng Gong, Siyuan Xu, Xinyi Li, Guihua Tian   +12 more
wiley   +1 more source

Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]

, 2018
The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
core   +1 more source

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Hyperplastic callus formation in congenital insensitivity to pain: A masquerader of osteosarcoma

Pediatric Hematology Oncology Journal, 2023
Background: Congenital insensitivity to pain (CIP) is a rare genetic disorder characterized by the inability to experience pain. Unrecognized, repeated injuries may result in poorly healed fractures with hyperplastic callus formation, auto-amputation of ...
Maha Anwar, Maha Rashid Malik, Shaarif Bashir, Usman Hassan, Alina Sadaf   +4 more
doaj   +1 more source