Results 61 to 70 of about 1,252,425 (189)

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, Volume 13, Issue 41, 22 July 2026.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Congenital Insensitivity to Pain and Anhidrosis: Dermoscopy of a Rare Genetic Disorder [PDF]

Indian Dermatology Online Journal
Balachandra S. Ankad, Shashank Devani, Sourab Dhananjaya, Ramesh Pol   +3 more
doaj   +2 more sources

Clinical and Genetic Spectrum of Filippi Syndrome: A Systematic Review of Published Case Reports and Case Series

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Filippi syndrome is a very rare autosomal recessive craniodigital disorder primarily caused by mutations in the gene CKAP2L, characterized by syndactyly, microcephaly, growth retardation, distinctive craniofacial features, and intellectual disability.
Muhammad Anas Faheem, Laraib Ghanghro, Ayesha Khan, Maryam Khalid, Salwa Bashir, Dania Iqbal, Adan Ali, Hussain Haider Shah, Sameer Abdul Rauf, Humaira Kalam   +9 more
wiley   +1 more source

Barriers to the Accessibility of Childcare Services for Children With Disabilities Aged 0 to 5 Years: Perspectives of Parents and Childcare Staff

Children &Society, Volume 40, Issue 4, Page 823-835, July 2026.
ABSTRACT According to Article 23 of the United Nations Convention on the Rights of the Child, children with disabilities are entitled to education, including access to high‐quality childcare services. Despite international and national commitments to inclusion, persistent obstacles continue to limit equitable access to childcare services for children ...
François Routhier, Josiane Lettre, Fidélia Longchamps, Gbetogo Maxime Kiki, Chantal Desmarais, Marie Grandisson, Ernesto Morales, Marie‐Eve Lamontagne, Francine Julien‐Gauthier, W. Ben Mortenson, Debra Field, Jill G. Zwicker, Wenonah Campbell, Michelle Phoenix, Marie‐Claude Belleau, Francine Tellier, Stéfanie Lamothe, Jason Gordon, Keely Edgington, Gabrielle Gagnon, Michelle Goulet, Anne‐Marie Guillot, Bobbi Taylor, Michelle Wan   +23 more
wiley   +1 more source

A case report of congenital insensitivity to pain and anhidrosis

, 2016
Congenital insensitivity to pain with anhidrosis (CIPA) is a rare disorder characterized by episodes of fever and pain insensitivity despite the fact that all other sensory modalities remain intact or minimally impaired.
Feroza Fatima, Nadia, Naseema Kapadia, Yosuf, Sehar Athar, Maryam Noshad, Maria, Maria Farooqi, Shehmona Faisal   +8 more
core   +1 more source

Nerve Growth Factor and the Physiology of Pain: Lessons from Congenital Insensitivity to Pain with Anhidrosis [PDF]

, 2012
Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder characterized by insensitivity to pain, anhidrosis (the inability to sweat) and mental retardation.
インドウ, ヤスヒロ, Indo, Yasuhiro, 犬童, 康弘   +2 more
core   +2 more sources

Single-Fiber Recordings of Nociceptive Fibers in Patients With HSAN Type V With Congenital Insensitivity to Pain

, 2016
Objectives: Nerve growth factor (NGF) is a protein important for growth and survival, but also for modulation of sensitivity of nociceptors and sympathetic neurons.
Dagrun Sagafos, Helås, Tormod, Sagafos, Dagrun,, Jorum, Ellen,, Roland Schmidt, Ellen Jørum, Minde, Jan,, Schmelz, Martin, Namer, Barbara,, Helas, Tormod,, Namer, Barbara, Tormod Helås, Inge P. Kleggetveit, Barbara Namer, Sagafors, Dagrun, Kleggetveit, Inge P., Schmelz, Martin,, Jan Minde, Kleggetveit, Inge P.,, Schmidt, Roland, Martin Schmelz, Jorum, Ellen, Schmidt, Roland,   +22 more
core   +1 more source

Walsh & Hoyt: Congenital Insensitivity to Pain

, 2005
Most of the patients with congenital insensitivity to pain have a type of hereditary sensory and autonomic neuropathy (HSAN). Some of the HSANs are characterized by distal loss of pain, temperature, light touch, and proprioceptive sensation.
Grant T. Liu, MD
core  

The Dental Management of a Child with Congenital Insensitivity to Pain

, 2010
Congenital insensitivity to pain is a rare condition present from birth. To date, congenital insensitivity to pain has been described in groups of hereditary sensory and autonomic neuropathies (HSAN).
S McKaig, A Hutton
core   +1 more source

Congenital Insensitivity to Pain without Anhidrosis: Orodental Problems and Management

Case Reports in Dentistry, 2015
This paper reports the case of a 4-year-old male patient who was brought by parents requesting for replacement of multiple missing anterior teeth. The patient suffered from congenital insensitivity to pain without anhidrosis and presented with full blown
N. Abdullah, Kausar Sadia Fakhruddin, A. R. Samsudin   +2 more
doaj   +1 more source