Results 51 to 60 of about 418,561 (266)

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

Pengaruh kompres hangat terhadap intensitas nyeri persalinan kala I fase aktif

Jurnal Kebidanan, 2020
Pain is an integral part of labor and childbirth which is normal due to physiological and psychological factors. Labor pain can affect uterine contractions through secretion of catecholamine and cortisol levels which increase sympathetic nervous system ...
Suyani Suyani
doaj   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Association between self-perceived pain sensitivity and pain intensity after cardiac surgery

Journal of Pain Research, 2018
Ann Kristin Bjørnnes,1,2 Irene Lie,3 Monica Parry,2 Ragnhild Falk,4 Marit Leegaard,5 Tone Rustøen,1,6 Berit Taraldsen Valeberg5 1Department of Research and Development, Division of Emergencies and Critical Care, Oslo University Hospital ...
Bjørnnes AK, Lie I, Parry M, Falk R, Leegaard M, Rustøen T, Valeberg BT   +6 more
doaj  

Genetic underpinnings and causal effects of brain structure and function on chronic pain intensity

Nature Communications
Chronic pain represents a major clinical burden, with its intensity being a key measure of its severity. However, the genetic and neural underpinnings of chronic pain intensity remain unraveled.
Xiuzhi Wang, Jinyu Liu, Xichen Wang, Jin Yang, Yipeng Le, Yingchao Song, Qian Su, Xiaoxiao Xiao, Yifan Li, Wen Qin, Chunshui Yu, Ping Wang, Meng Liang   +12 more
doaj   +1 more source

Pain Intensities

Philosophy and Phenomenological Research
ABSTRACT Recent philosophical work on pain distinguishes a variety of pain qualities and the mechanisms that give rise to them, but pain intensity remains a monolithic notion difficult to account for in reductive terms. The reason for this difficulty is that pain intensity is not a unitary phenomenal magnitude; pain is a complex ...
openaire   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

Juvenile Huntington Disease With Cerebellar‐Predominant Atrophy Identified by Genome Sequencing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Juvenile Huntington disease accounts for a small fraction of Huntington disease cases and is driven by the largest trinucleotide repeat expansions. We describe a 6‐year‐old boy with progressive global regression, generalized dystonia, and epilepsy, in whom serial imaging showed striking cerebellar‐predominant atrophy with an initially normal ...
Enrique Gonzalez Saez‐Diez, Amy Tam, Siofra Carty, Monica Ferrer Socorro, Kathryn Yang, Darius Ebrahimi‐Fakhari   +5 more
wiley   +1 more source

Pain distribution, intensity, and duration in patients with chronic pain

Journal of Pain and Symptom Management, 1989
This study examined the impact of two dimensions of pain distribution (extent, site) on patient reports of pain intensity and duration among 105 patients with chronic pain. Pain extent was found to be associated strongly with reports of pain intensity and pain duration.
S J, Krause, R C, Tait, R B, Margolis
openaire   +2 more sources