Results 31 to 40 of about 2,003,224 (310)

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Glial Fibrillary Acidic Protein Astrocytopathy Based on a Two‐Center Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glial fibrillary acidic protein astrocytopathy (GFAP‐A) is a recently defined nosological form belonging to the class of autoimmune inflammatory disorders affecting the central nervous system (CNS). Here, we report the clinical and MRI characteristics, treatment, and prognosis of a GFAP‐A cohort from two centers in China.
Ti Wu, Hao Zhang, Chao Gao, Qiuhua Yu, Moli Fan, Lin‐Jie Zhang, Haipeng Zhang, Hengri Cong, Yuzhen Wei, Chotima Böttcher, Alexej Verkhratsky, Friedemann Paul, Fu‐Dong Shi, Tian Song   +13 more
wiley   +1 more source

Efficacy of nonsurgical interventions for anterior knee pain: Systematic review and meta-analysis of randomized trials [PDF]

, 2012
Anterior knee pain is a chronic condition that presents frequently to sports medicine clinics, and can have a long-term impact on participation in physical activity.
, Akarcali, Aminaka, Arroll, Bakhtiary, Ballas, Baquie, Barton, Barton, Bill Vicenzino, Bily, Bizzini, Brantingham, Brosseau, Callaghan, Callaghan, Clark, Clement, Collins, Collins, Collins, Crossley, Crossley, Crossley, Davis, DeHaven, Denton, Devereaux, Dursun, Escamilla, Finestone, Harrison, Heintjes, Heintjes, Herbert, Herrington, Higgins, Higgins, Hossain, Jensen, Kay M. Crossley, Kettunen, Kujala, Leanne M. Bisset, Liberati, Lun, Matheson, Milgrom, Miller, Moher, Moher, Moller, Nakagawa, Natalie J. Collins, Nimon, Powers, Prins, Qiu, Rogvi-Hansen, Salaffi, Schneider, Song, Stakes, Suter, Syme, Taylor, Utting, van den Dolder, van Linschoten, van Middelkoop, Warden, Whittingham, Wiener-Ogilvie, Witvrouw, Witvrouw, Witvrouw, Yip   +76 more
core   +1 more source

Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population‐based cohort, which provided clinical ...
Andrea Nova, Teresa Fazia, Giovanni Di Caprio, Davide Gentilini, Luisa Bernardinelli, Roberto Bergamaschi   +5 more
wiley   +1 more source

Pain as metaphor: metaphor and medicine [PDF]

Medical Humanities, 2015
Like many other disciplines, medicine often resorts to metaphor in order to explain complicated concepts that are imperfectly understood. But what happens when medicine's metaphors close off thinking, restricting interpretations and opinions to those of the negative kind?
openaire   +2 more sources

Combination of Rehabilitative Therapy with Ultramicronized Palmitylethanolamide for Chronic Low Back Pain: An Observational Study [PDF]

, 2019
Chronic low ba,:k pain (LBP) caused by intervertebral disc herniation was reported in the 2010 Global Burden of Disease study to be the main reason for;zears lived wittL disability. It causes significant personal, social, and economic burdens.
Chiara Asaro, Dalila Scaturro, Giulia Letizia Mauro, Giustino Varrassi, Lorenza Lauricella, Sofia Tomasello   +5 more
core   +1 more source

Remaining Burden of Spinal Muscular Atrophy Among Treated Patients: A Survey of Patients and Caregivers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinal muscular atrophy (SMA) significantly impacts motor function. This study aimed to assess the persistent burden and unmet needs among currently treated patients with SMA and their caregivers. Methods Two complementary web‐based surveys were distributed in August 2024 among patients with SMA and their caregivers.
Julie A. Parsons, Natalie Land, Melissa Culhane Maravic, Claire Cagle, Amal Jamaleddine, Hemal Shah, Thomas Brown, Christabella Cherubino, Mouhamed Gueye   +8 more
wiley   +1 more source

Attitudes towards Complementary Medicine in Patients with Musculoskeletal Pain [PDF]

, 2018
The epidemic of opiate use-related deaths has become a public health crisis and has highlighted the potentially lethal effects of opiates. Vermont has adopted new laws to address the prescription of opiates, which has reduced the number of prescriptions ...
Vines, Caroline
core   +1 more source

Discovery and Treatment of Action Potential‐Independent Myotonia in Hyperkalemic Periodic Paralysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hyperkalemic periodic paralysis (hyperKPP) is characterized by attacks of transient weakness. A subset of hyperKPP patients suffers from transient involuntary contraction of muscle (myotonia). The goal of this study was to determine mechanisms causing myotonia in hyperKPP.
Chris Dupont, Adam Deardorff, Murad Nawaz, Andrew A. Voss, Mark M. Rich   +4 more
wiley   +1 more source

Cannabis shenanigans: advocating for the restoration of an effective treatment of pain following spinal cord injury. [PDF]

, 2018
Cannabis is an effective treatment for pain following spinal cord injury that should be available to patients and researchers. The major argument against the rescheduling of cannabis is that the published research is not convincing.
Graves, PhD, Daniel E.
core   +1 more source