Results 201 to 210 of about 176,534 (288)

Minimal Reduction in Patellar Height Following Anteromedializing Tibial Tubercle Osteotomy With Medial Patellofemoral Ligament Reconstruction

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To assess whether anteromedializing tibial tubercle osteotomy (AMZ TTO) results in reduction in patellar height when performed alongside medial patellofemoral ligament reconstruction (MPFLR) for the treatment of patellar instability. Methods We performed a retrospective review of patients who underwent AMZ TTO with MPFLR between 2017 and 2024 ...
Divesh Sachdev, Cade Smelley, Jay Amin, Christopher Song, Daniel Shinn, Nicholas Lemme, Brian Cole, Adam B. Yanke   +7 more
wiley   +1 more source

Arthroscopic Partial Repair and Arthroscopic Debridement Improve Pain and Functional Outcomes in Older Patients With Massive Irreparable Rotator Cuff Tears: A Systematic Review

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate the current evidence on patient‐reported outcomes and complications after arthroscopic partial repair and arthroscopic debridement for massive irreparable rotator cuff tears (MIRCTs) in patients aged 65 years or older. Methods A systematic search of MEDLINE, Embase, and Cochrane Library databases was conducted through September 2025
Dave Osinachukwu Duru, Andrew Kailin Zhou, Rahul Geetala, Andrew Metcalfe, Salma Chaudhury   +4 more
wiley   +1 more source

Anterior Knee Unloader Brace Prescription Yields Moderate Compliance Rates and Improved Clinical Function in Patients with Patellofemoral Pain

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To determine clinical outcome changes and wear compliance rates associated with the use of a custom‐fit anterior knee unloader brace in a prospective cohort of patients with clinical symptoms derived from patellofemoral osteoarthritis (PFOA).
Andrew R. Phillips, Thomas Moran, Kofi K. Acheampong, Stephanie A. Boden, Erik C. Haneberg, William D. Bugbee, John P. Fulkerson, Simon Goertz, John G. Lane, Sabrina M. Strickland, Adam B. Yanke   +10 more
wiley   +1 more source

The Presence of Chondral Pathology Is Not Associated With an Increase in Meniscal Root Retear, Reoperation, or Subsequent Total Knee Arthroplasty Rates

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To identify whether chondral pathology is associated with an increase in failure rates of isolated meniscal root repairs. Methods We retrospectively reviewed meniscus repairs from 2012 to 2022 at the author's institution. Nonroot repairs and cases with total or same compartment meniscectomy, cartilage restoration, osteotomy, or other concurrent
Matthew D. Benson, Richard J. VanTienderen, Austin C. Benson, Benjamin D. Packard, Steven M. Leary, Kyle R. Duchman, Brian R. Wolf, Robert W. Westermann   +7 more
wiley   +1 more source

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

Arthritis &Rheumatology, EarlyView.
Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)‐approved disease‐modifying therapies for SjD. In this review, we
Rachael A. Gordon, Sara S. McCoy
wiley   +1 more source

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, EarlyView.
Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and posttranscriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron splicing ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Efficacy and Safety of Guselkumab in Participants With Active Psoriatic Arthritis After Inadequate Response to One Prior Tumor Necrosis Factor Inhibitor: Week‐24 Results of a Phase 3, Randomized, Placebo‐Controlled Study

Arthritis &Rheumatology, EarlyView.
Objective To evaluate the efficacy and safety of guselkumab, an interleukin‐23p19 subunit inhibitor, in participants with active psoriatic arthritis (PsA) and inadequate response (inadequate efficacy and/or intolerance) to one prior tumor necrosis factor (TNF) inhibitor.
Alexis Ogdie, Joseph F. Merola, Philip J. Mease, Christopher T. Ritchlin, Jose U. Scher, Kimberly Parnell Lafferty, Daphne Chan, Soumya D. Chakravarty, Wayne Langholff, Yanli Wang, Jie Shao, Yevgeniy Krol, Alice B. Gottlieb   +12 more
wiley   +1 more source

Tissue‐Specific and Spatially Dependent Metabolic Signatures Perturbed by Injury in Male and Female Mice

Arthritis &Rheumatology, EarlyView.
Objective Osteoarthritis, the leading cause of disability worldwide, disproportionately affects women, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven, Avery H. Welfley, Priyanka P. Brahmachary, Mark Greenwood, Donald F. Smith, Brian Bothner, Ronald K. June   +6 more
wiley   +1 more source

PEPITEM Regulates the Synovial Microenvironment During Immune‐Mediated Inflammatory Arthritis to Limit Disease

Arthritis &Rheumatology, EarlyView.
Objective Here we investigate the status of the adiponectin–PEPITEM pathway in early, treatment naive rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and the therapeutic efficacy of PEPITEM administration in preclinical models. Methods Peripheral blood was isolated from patients with clinical suspect arthralgia and suspected inflammatory ...
Mussarat Wahid, Samuel Kemble, Oladimeji Abudu, Anella Saviano, Christopher Mahony, Jonathan W. Lewis, Thomas A. Nicholson, Anna Schettino, Noemi Marigliano, Kathryn Frost, Jenefa Begum, Alyssa M. Urbanowski, Marion Limo, Rakesh Jha, Sandra Martinez Jarquin, Laleh Pezhman, Abbie E. A. Degan, Amy E. Anderson, Charlotte G. Smith, Armaiti Batki, Holly Adams, Francesco Caso, Raffaele Scarpa, Iain McInnes, Stefan Siebert, Arthur G. Pratt, Andrew Filer, Karim Raza, Adam P. Croft, Myriam Chimen, Felicity de Cogan, G. Ed Rainger, Asif J. Iqbal, Francesco Maione, Helen M. McGettrick   +34 more
wiley   +1 more source

Ixekizumab With Tirzepatide Achieved Greater Disease Control Than Ixekizumab Alone in Adults With Psoriatic Arthritis and Overweight or Obesity: Results From a Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective Overweight or obesity is prevalent in 72% to 82% of individuals with psoriatic arthritis (PsA). We assessed the efficacy and safety of ixekizumab (IXE) concomitantly administered with tirzepatide (TZP) compared with IXE alone in adult participants with active PsA and overweight with at least one weight‐related comorbidity or obesity.
Joseph F. Merola, Philip Mease, Alan Kivitz, Naveed Sattar, Laura C. Coates, Daniel Aletaha, Cynthia E. Kartman, Peter Fischer, Luna Sun, Píndaro Martínez‐Osuna, Andris Kronbergs, Purvi Prajapati, Anabela Cardoso, Mark C. Genovese, Alexis Ogdie   +14 more
wiley   +1 more source