Results 61 to 70 of about 176,534 (288)

A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers

Drug Design, Development and Therapy, 2017
Jieon Lee,1 Bo-Hyung Kim,2 Kyung-Sang Yu,1 Hee Sun Kim,3 Ji Duck Kim,4 Joo-Youn Cho,1 SeungHwan Lee,1 Namyi Gu5 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 2Department of Clinical ...
Lee J, Kim BH, Yu KS, Kim HS, Kim JD, Cho JY, Lee S, Gu N   +7 more
doaj  

Associations between cognitive test scores and pain tolerance: The Tromsø study [PDF]

The aim of this study is to assess this relationship in a large population-based sample. Methods ‒ We included 5,753 participants (aged 40–84 years) from the seventh wave of the population-based Tromsø Study who had been examined with cognitive tests
Nielsen, Christopher S., Stubhaug, Audun, Schirmer, Henrik, Jacobsen, Henrik B., Mathiesen, Ellisiv B., Melum, Tonje Anita, Steingrímsdóttir, Ólöf A., Johnsen, Bente   +7 more
core   +1 more source

Direct Metal Deposition of Graphene–Ti28Nb35.4Zr Matrix Composites With Enhanced Mechanical, Corrosion, and Biocompatibility Properties for Bone Implants

Advanced Engineering Materials, EarlyView.
Graphene nanoplatelet (0.1 wt.%) reinforcement significantly enhances the performance of β Ti‐28Nb‐35.4Zr alloy. Grain refinement, reduced water contact angle, and improved surface characteristics promote osteoblast adhesion and complete surface coverage after 7 days.
Khurram Munir, Jixing Lin, Yuncang Li, Li Zhu, Paul F. A. Wright, Cuie Wen   +5 more
wiley   +1 more source

Investigating mortality salience as a potential causal influence and moderator of responses to laboratory pain [PDF]

PeerJ
Background Because pain can have profound ramifications for quality of life and daily functioning, understanding nuances in the interplay of psychosocial experiences with pain perception is vital for effective pain management.
Beibei You, Hongwei Wen, Todd Jackson
doaj   +2 more sources

Dopamine transporter genotype dependent effects of apomorphine on cold pain tolerance in healthy volunteers. [PDF]

PLoS ONE, 2013
The aims of this study were to assess the effects of the dopamine agonist apomorphine on experimental pain models in healthy subjects and to explore the possible association between these effects and a common polymorphism within the dopamine transporter ...
Roi Treister, Dorit Pud, Richard P Ebstein, Elon Eisenberg   +3 more
doaj   +1 more source

A Dislocation Perspective on Strength and Toughness in Ceramics

Advanced Engineering Materials, EarlyView.
Dislocations in ceramics enjoy a long but yet under‐appreciated history. The three research waves for dislocations in ceramics highlight the topic evolution over the last 90 years. This review focuses on the impact of dislocation on strength and toughness in ceramics.
Xufei Fang
wiley   +1 more source

Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation

Advanced Healthcare Materials, EarlyView.
Surface‐host dialogue at the implant interface governs biological fate and osseointegration. Surface physicochemical properties of titanium (Ti) dental implants, including microgrooves, nanopatterns, nanotopography, roughness, and wettability, modulate the initial adsorption of proteins and the formation of a dynamic biointerface.
Daniela Moreira Cunha, Amanda Paino Santana, Marta Maria Alves Pereira, Mariana Martins Guerreiro, Jose Mauro Granjeiro, Jamil Awad Shibli, Jeroen J. J. P. van den Beucken, Anton Sculean, Rafael Scaf de Molon, Erica Dorigatti de Avila   +9 more
wiley   +1 more source

Chronic stress moderates the impact of social exclusion on pain tolerance: an experimental investigation

Journal of Pain Research, 2017
Karoline Pieritz,1 Sarina J Schäfer,2 Jana Strahler,3 Winfried Rief,1 Frank Euteneuer1 1Division of Clinical Psychology and Psychotherapy, Philipps Universität, Marburg, 2Division of Psychological Methods and Evaluation, Fernuniversität ...
Pieritz K, Schäfer SJ, Strahler J, Rief W, Euteneuer F   +4 more
doaj  

Effect of Two Doses of Oral Melatonin on Perioperative Anxiety and Postoperative Analgesia in Patients Undergoing Orthopaedic Surgeries: A Randomised Controlled Study

Journal of Clinical and Diagnostic Research
Introduction: Perioperative anxiety and postoperative pain are the most common complaints associated with orthopaedic surgeries leading to increased morbidity and hospital stay.
Lisa Barman, Shashi Kiran, Mamta Jain, Neha Aeron, Amandeep Singh Sachdeva, Amit Singh   +5 more
doaj   +1 more source

Inter-strain differences of serotonergic inhibitory pain control in inbred mice

, 2010
Background: Descending inhibitory pain control contributes to the endogenous defense against chronic pain and involves noradrenergic and serotonergic systems.
Albuquerque Boris, Irmgard Tegeder, Tegeder Irmgard, Laura Popp, Wijnvoord, Nina, Myrczek, Thekla, Tegeder, Irmgard, Wijnvoord Nina, Popp, Laura, Annett Häussler, Häussler, Annett, Nina Wijnvoord, Myrczek Thekla, Häussler Annett, Popp Laura, Boris Albuquerque, Albuquerque, Boris, Thekla Myrczek   +17 more
core   +1 more source