Results 121 to 130 of about 1,100,408 (397)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Where Have All the Symbols Gone?: A Study of Sufis and Sufi Symbolism in Ottoman Miniature Paintings
, 2013 Ottoman miniature paintings represent some of the best preserved and documented works of Islamic art still extant. They differ critically from other forms of miniature painting, such as Persian miniature painting, by not representing Sufi symbolism.
Siegel, Jesse E.
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Studying Form, Color, and Pictorial Composition in the New England Landscape [PDF]
, 2017 When I applied for a grant through the Research and Apprenticeship Program (REAP) at the University of New Hampshire (UNH) during the spring of 2016, my intention was to gain more experience in the art of painting outdoors. By looking through the student
Faiella, Daniel
core +1 more source
Digital Twin for a Collaborative Painting Robot [PDF]
, 2022 Ratchatin Chancharoen +5 more
openalex +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
The role of multiple materials to enrich contemporary mural painting
الاكاديميThe research presents a study on multiple materials and various media in enriching contemporary mural painting in a visual space that allows the formation of a perception enriches the aesthetic vision in the artistic work. Through the diversity of media
Ayad Abdulkareem Mayea +2 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Zeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-BiałejThis article analyzes how paints and coatings businesses in the USA and Kazakhstan scale between 2019 and 2023. The research employs a non-linear econometric model to identify key factors, including market size, innovation, supply chain efficiency and ...
Andrey Chshelokovskiy
doaj +1 more source