Results 101 to 110 of about 402,362 (305)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The manifestations of West and East Societies in Victorian Paintings in England and Orientalist Paintings in the mid-19th cent (a comparative study)

Maǧallaẗ Al-Turāṯ wa Al-Taṣmīm
The paintings of the Victorian era in England and the paintings of Orientalism are regarded as a kind of historical and documentary monitoring of the significant details of each Britain's social and significant life through analysis of Victorian ...
Dr. Nihad Mohamed Sadek
doaj   +1 more source

Rehabilitation of an orbital defect using a silicone prosthesis with a custom ocular portion – A case report

Journal of Dr. NTR University of Health Sciences
The surgical removal of the orbit can be a psychologically traumatic event that may incapacitate patients. The prosthetic rehabilitation of such defects is complex and artistically driven.
Janaki Ramesh, Sreeramulu Basapogu, Vineela Pyla, Bharat C. Velamakuri   +3 more
doaj   +1 more source

FROM HARD WORK TO RESISTANCE: CENTRALITY OF THE IMAGE OF HANDS IN THE ARTWORKS OF SLOVENIAN REGIONALIST PAINTER IVE ŠUBIC [PDF]

Trames
The article explains the aesthetic element of the hand in the artworks of Slovenian regionalist painter Ive Šubic (1922–1989). It elaborates the reasons why the author believes that Šubic’s work was a unique combination of regionalism and partisan ...
Tomaž Krpič
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Paintings of War, Museums of Memory [PDF]

, 2017
This paper examines the artists sent to the Western Front under Britain’s official war artists initiative. The government sought to utilize artwork for propagandistic purposes, and to foster emotional connection between civilian and soldier. However, the
Waters, Laura G.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Entre texte et image : réflexions sur la traduction des titres de tableaux de Paul Gauguin

Studia Romanica Posnaniensia, 2021
The aim of this article is to analyse the translation strategies used to translate Paul Gauguin’s painting titles from Tahitian and French to Polish. We will analyse the titles that the artist painted directly on the canvases by making them invariant ...
Barbara Walkiewicz
doaj