Results 81 to 90 of about 148,105 (292)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Beauty and the bulls: the investment characteristics of paintings [PDF]
An examination of the investment and consumption characteristics of the paintings market between 1971 and 1984, using the capital asset pricing model.Investments ; Capital assets pricing ...
Michael F. Bryan
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Optical and material properties of varnishes for paintings [PDF]
, 2011 Clear varnish coatings are applied to the surface of historic paintings to provide a protective barrier layer and/or change their appearance. The natural varnishes used by the original artist would have given the painting its original finished appearance.
Lawman, SJ
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
"Prices for Paintings by African American Artists and Their Contemporaries: Does Race Matter? (Revision of Working Paper No. 2006-06)" [PDF]
This paper investigates the extent that economic markets have incorporated mainstream artistic acceptance of African American art. Price levels and movements for paintings by African American artists versus their white contemporaries are compared using ...
Richard Agnello, Xiaowen Xu
core
Medisan, 2013 Tomando como punto de partida la obra del artista santiaguero Juan Emilio Hernández Giro y, en específico, el inicio y fin de la vida expresados mediante la pintura, surgió la motivación para efectuar este artículo, en el cual se caracterizan el ...
María Elena Guerra Felíu +2 more
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Genetic Paint: A Search for Salient Paintings
, 2005 The contribution of this paper is a novel non-photorealistic rendering (NPR) algorithm for rendering real images in an impasto painterly style. We argue that figurative artworks are salience maps, and develop a novel painting algorithm that uses a genetic algorithm (GA) to search the space of possible paintings for a given image, so approaching an ...
John P. Collomosse, Peter M. Hall
openaire +3 more sources