Results 101 to 110 of about 156,506 (289)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Physiological implications of pair-bond status in greylag geese

, 2011
In group-living vertebrates, reliable social allies play a decisive role in dealing with stressors. For example, support by social allies is known to dampen glucocorticoid responses.
Walter Arnold, Brigitte M. Weiß, Kurt Kotrschal, Claudia A. F. Wascher   +3 more
core   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Bis{bis[2-(diisopropylphosphanyl)phenyl]phosphanido-κ3P,P′,P′′}chloridonickel(II)

Acta Crystallographica Section E, 2012
In the title compound, [Ni(C24H36P3)Cl], the NiII atom adopts a distorted square-planar geometry with the two neutral P atoms of the tridentate ligand trans to one another.
Consiglia Tedesco, Marina Lamberti, Mina Mazzeo   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

MODEL-CALCULATIONS OF CHEMICAL INTERACTIONS .3. ROTATIONAL ENERGY PROFILES IN SIMPLE MOLECULES - EVALUATION, ADDITIVITY AND ROLE OF BOND BOND, BOND LONE-PAIR AND LONE-PAIR LONE-PAIR INTERACTIONS

, 1991
Rotational isomerism in ethane, methylamine, methanol, fluoromethylamine, hydrazine, hydroxylamine, hydrogen peroxide and difluorine dioxide has been analysed using basis sets of symmetrically orthogonalized hybrid AOs.
RASTELLI A, COCCHI, Marina
core  

An experiment on the function of the long-term pair bond period in the socially monogamous bearded reedling

, 2011
Pair bond duration and age are suggested to be important determinants for reproductive success in long-term monogamous pair bonding. These two effects are generally difficult to separate, however, and experimental approaches are scarce. We experimentally
Matteo Griggio, Herbert Hoi, GRIGGIO, MATTEO   +2 more
core   +1 more source

Influence of lone-pair activity on the bond parameters of lead bromide, lead chloride and lead oxide [PDF]

, 2020
Lead Pb(II) is challenging environment to study because it has electron lone pair, coordination number would vary from 2 to 10. The current study chooses chlorine, oxygen and bromine as coordination atoms because it bonded with one type of element in ...
Al Maamari, Badar Salim Hamed
core  

Bond-Dissociation Energies to Probe Pyridine Electronic Effects on Organogold(III) Complexes: From Methodological Developments to Application in π‑Backdonation Investigation and Catalysis

, 2023
In this work, we report on the synthesis of several organogold(III) complexes based on 4,4′-diterbutylbiphenyl (C^C) and 2,6-bis(4-terbutylphenyl)pyridine (C^N^C) ligands and bond with variously substituted pyridine ligands (pyrR).
Denis Lesage, Héloïse Dossmann, Lyna Bourehil (16813045), Geoffrey Gontard (1813603), Benoît Bertrand (1845097), Denis Lesage (1581142), Clément Soep (16813048), Héloïse Dossmann (1714588), Stacy Igoudjil (16813057), Sarah Dutrannoy, Jérémy Forté (14773345), Lyna Bourehil, Sopheak Seng (16813051), Sopheak Seng, Sarah Dutrannoy (16813054), Jérémy Forté, Stacy Igoudjil, Clément Soep, Benoît Bertrand, Geoffrey Gontard   +19 more
core   +1 more source