Results 111 to 120 of about 2,093,493 (279)
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source
The paired-domination and the upper paired-domination numbers of graphs
Tyt. z nagłówka.Bibliogr. s. 134-135.In this paper we continue the study of paired-domination in graphs. A paired-dominating set, abbreviated PDS, of a graph G with no isolated vertex is a dominating set of vertices whose induced subgraph has a perfect ...
Ulatowski, Włodzimierz.
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Paired Domination on Cactus Graphs
, 2017 本論文提出一個演算法來解決仙人掌圖上的成對支配點問題。試想一個由點與線構成的圖,支配集是圖上的點構成的點集合,而圖上每個不在支配集裡的點都會至少與一個在支配集裡的點相鄰,如此就構成了支配集。而對於一個圖上的成對支配點集來說,既滿足支配集的定義又滿足支配集裡點形成的誘導子圖上,點兩兩成對。在一個圖上無數成對支配集中,如何找到一個成對支配集且此集合點的數量為無數成對支配點中最少的,就是成對支配點問題。此外,只要一張連通圖是由許多環或邊組成,且任意兩環只會有一個共同交點,就稱之為仙人掌圖 ...
Huang, Tzu-Hsuan, 黃子軒
core +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Paired versus double domination in K 1,r -free graphs
, 2014 International audienceA vertex in G is said to dominate itself and its neighbors. A subset S of vertices is a dominating set if S dominates every vertex of G. A paired-dominating set is a dominating set whose induced subgraph contains a perfect matching.
Henning, Michael, Antony +2 more
core +1 more source