Results 161 to 170 of about 856,388 (330)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Pair extended coupled cluster doubles [PDF]

, 2015
Thomas M. Henderson, Ireneusz W. Bulik, Gustavo E. Scuseria   +2 more
openalex   +1 more source

Confinement of relativistic electrons in a magnetic mirror en route to a magnetized relativistic pair plasma [PDF]

, 2021
Jens von der Linden, G. Fiksel, J. Peebles, Matthew R. Edwards, L. Willingale, A. Link, D. Mastrosimone, Hui Chen   +7 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Enhancing outage performance and sum capacity in multi-user environments through IOS-aided hybrid NOMA under imperfect SIC

EURASIP Journal on Wireless Communications and Networking
This study investigates the potential of integrating passive intelligent omni surface (IOS) technology to enhance wireless communication within a hybrid non-orthogonal multiple access (NOMA) system.
Helen Sheeba John Kennedy, Vinoth Babu Kumaravelu   +1 more
doaj   +1 more source

Zygotic pioneer factor activity of Odd-paired/Zic is necessary for late function of the Drosophila segmentation network

, 2020
Isabella V Soluri, Lauren M Zumerling, Omar A. Payán Parra, Eleanor G. Clark, Shelby A. Blythe   +4 more
openalex   +1 more source

Disordered Kitaev chain with long-range pairing: Loschmidt echo revivals and dynamical phase transitions [PDF]

, 2020
Utkarsh Mishra, R. Jafari, Alireza Akbari   +2 more
openalex   +1 more source

The kinetics of carbon pair formation in silicon prohibits reaching thermal equilibrium [PDF]

, 2023
Péter Deák, Péter Udvarhelyi, Gergő Thiering, Ádám Gali   +3 more
openalex   +1 more source

Transparent Pairs

Journal of Geometric Analysis, 2011
Minor ...
openaire   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source