Results 171 to 180 of about 2,507,103 (386)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Enhancing outage performance and sum capacity in multi-user environments through IOS-aided hybrid NOMA under imperfect SIC

open access: yesEURASIP Journal on Wireless Communications and Networking
This study investigates the potential of integrating passive intelligent omni surface (IOS) technology to enhance wireless communication within a hybrid non-orthogonal multiple access (NOMA) system.
Helen Sheeba John Kennedy   +1 more
doaj   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Symmetry restoration in the mean-field description of proton-neutron pairing

open access: yesPhysics Letters B, 2019
We show that the symmetry-restored paired mean-field states (quasiparticle vacua) properly account for isoscalar versus isovector nuclear pairing properties. Full particle-number, spin, and isospin symmetries are restored in a simple SO(8) proton-neutron
A.M. Romero, J. Dobaczewski, A. Pastore
doaj  

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