Results 131 to 140 of about 30,176 (325)
Advanced Genetics, Volume 6, Issue 1, March 2025.This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley +1 more source
Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen +10 more
wiley +1 more source
International Journal of Cancer, EarlyView.Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer +11 more
wiley +1 more source
Metagenomic mining reveals novel Cas12 subtypes and their evolutionary diversification
iMetaOmics, EarlyView.We identified 4112 Cas12 Proteins and 6 new Cas12 subtypes, revealed their significant diversity in N‐terminal regions, repeat sequences, and sequences motifs. We developed an AI‐driven algorithm, Cas12fam, which allows precise annotation of 18 distinct domains in Cas12 proteins.
Meixia Yu +11 more
wiley +1 more source
iNew Medicine, EarlyView.ABSTRACT Psoriasis is a chronic autoimmune disease characterized by systemic inflammation and skin involvement, affecting millions of individuals worldwide. However, few studies have evaluated whether psoriasis and cardiac magnetic resonance imaging (CMR) traits share a common genetic basis.
Junlin Yang +8 more
wiley +1 more source
CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling
Med Research, EarlyView.CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li +8 more
wiley +1 more source
Association of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Elements with Specific Serotypes and Virulence Potential of Shiga Toxin-Producing Escherichia coli [PDF]
, 2013 Magaly Toro +7 more
openalex +1 more source
Pest Management Science, EarlyView.An environmental DNA (eDNA)‐based recombinase polymerase amplification (RPA)‐CRISPR/Cas12a assay enables rapid, specific, and on‐site detection of chironomids, supporting early warning, and ecological monitoring in freshwater environments. Abstract BACKGROUND Freshwater chironomid midges pose a significant threat to drinking water quality and ...
Kyuhyeong Kim +5 more
wiley +1 more source