Results 21 to 30 of about 11,659 (270)

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management

Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022
Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem, Mohammed A Alsahli, Ahmad Almatroudi, Faris Alrumaihi, Fahd Khaleefah Alkhaleefah, Arshad Husain Rahmani, Amjad Ali Khan   +6 more
wiley   +1 more source

Human AZFb deletions cause distinct testicular pathologies depending on their extensions in Yq11 and the Y haplogroup: new cases and review of literature

Cell & Bioscience, 2021
Genomic AZFb deletions in Yq11 coined “classical” (i.e. length of Y DNA deletion: 6.23 Mb) are associated with meiotic arrest (MA) of patient spermatogenesis, i.e., absence of any postmeiotic germ cells.
P. H. Vogt, U. Bender, B. Deibel, F. Kiesewetter, J. Zimmer, T. Strowitzki   +5 more
doaj   +1 more source

Epipolythiodioxopiperazine‐Based Natural Products: Building Blocks, Biosynthesis and Biological Activities

ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022
Housing sulfur: Certain fungi produce diketopiperazine compounds with a transannular sulfur bridge. These so‐called epipolythiodioxopiperzines are toxic by non‐specifically interacting with intracellular proteins and contribute to fungal pathogenicity. Producer strains serve as bio‐pesticides but also question safety of food fermentation.
Eva M. Huber
wiley   +1 more source

Whole Genome Sequence Analysis of Mutations Accumulated in rad27Δ Yeast Strains with Defects in the Processing of Okazaki Fragments Indicates Template-Switching Events

G3: Genes, Genomes, Genetics, 2017
Okazaki fragments that are formed during lagging strand DNA synthesis include an initiating primer consisting of both RNA and DNA. The RNA fragment must be removed before the fragments are joined. In Saccharomyces cerevisiae, a key player in this process
Sumita Omer, Bar Lavi, Piotr A. Mieczkowski, Shay Covo, Einat Hazkani-Covo   +4 more
doaj   +1 more source

In girum imus nocte et consumimur igni. L’étendard de Guy Debord

Cahiers de Narratologie, 2009
Vingt et un ans après le Rapport sur la construction des situations de 1957, qu’on peut considérer comme le manifeste fondateur de l'Internationale Situationniste, Guy Debord, « se disant cinéaste », a tourné en 1978 son dernier long métrage, In girum ...
Serge Milan
doaj   +1 more source

Characterization of the integration and modular excision of the integrative conjugative element PAISt in Streptomyces turgidiscabies Car8. [PDF]

PLoS ONE, 2014
PAISt is a large genomic island located in the chromosome of the plant pathogen Streptomyces turgidiscabies Car8. The island carries clustered virulence genes, transfers to other Streptomyces species, and integrates by site-specific recombination at the ...
Jose C Huguet-Tapia, Dawn R D Bignell, Rosemary Loria   +2 more
doaj   +1 more source

Myc oncogene-induced genomic instability: DNA palindromes in bursal lymphomagenesis. [PDF]

PLoS Genetics, 2008
Genetic instability plays a key role in the formation of naturally occurring cancer. The formation of long DNA palindromes is a rate-limiting step in gene amplification, a common form of tumor-associated genetic instability.
Paul E Neiman, Katrina Elsaesser, Gilbert Loring, Robert Kimmel   +3 more
doaj   +1 more source

Synthetic mutualism in engineered E. coli mutant strains as functional basis for microbial production consortia

Engineering in Life Sciences, Volume 23, Issue 1, January 2023., 2023
Abstract In nature, microorganisms often reside in symbiotic co‐existence providing nutrition, stability, and protection for each partner by applying “division of labor.” This principle may also be used for the overproduction of targeted compounds in bioprocesses.
Tobias Müller, Simon Schick, Jonathan Beck, Georg Sprenger, Ralf Takors   +4 more
wiley   +1 more source

A companion to the preclinical common data elements for rodent genetic epilepsy models. A report of the TASK3‐WG1B: Paediatric and genetic models working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting the cost‐effectiveness and scientific rigor of the studies performed.
Massimo Mantegazza, Stėphane Auvin, Melissa Barker‐Haliski, Anna‐Maria Katsarou, Hana Kubova, Aristea S. Galanopoulou, Bridgette Semple, Christopher A. Reid   +7 more
wiley   +1 more source

Poetic Dialogue from the Periphery of World Literature: Goethe’s Faust and the Korean Novel Kumo-shinwha

Interlitteraria, 2018
A short but cardinal passage of Goethe’s Faust is the rhymed dialogue between Faust and Helen at their first encounter: the depiction of the very idealistic encounter consists of the process by which the ancient Greek mythical figure Helen learns about ...
Young-Ae Chon
doaj   +1 more source