Results 81 to 90 of about 22,766 (265)
Harnessing chimeric antigen receptor macrophages against solid tumors
Cancer Communications, EarlyView.Abstract Macrophages are prevalent in multiple tumors and exhibit diverse and potent functional activities. Therapeutic reprogramming of macrophage phenotypes represents a promising strategy for cancer immunotherapy. Engineering chimeric antigen receptors (CARs) to endow macrophages with anti‐tumor capacities demonstrated encouraging efficacy ...
Mengru Wang +3 more
wiley +1 more source
Palindromic-Type Squared Expressions with Palindromic and Non-Palindromic Sums - I
, 2019 In the previous papers, the author worked with palindromic-type expressions. These expressions are by use of operations of addition and multiplications. When the operations are removed, we get normal even order palindromes. The previous works are limited to particular cases including patterns.
openaire +3 more sources
ChemBioChem, EarlyView.Hetero‐tetramer dysfunction: Li–Fraumeni syndrome (LFS) is a hereditary cancer predisposition caused by mutations in the TP53 gene encoding the tumor suppressor p53. It is shown that p53 variants R337C and R337H, found in LFS, impair wild‐type (WT) p53 function by forming heterotetramers with reduced transcriptional activity.
Rui Kamada +6 more
wiley +1 more source
Discrete length of palindromic segments from Tetrahymena DNA [PDF]
, 1980 S.N. Borchsenius +1 more
openalex +1 more source
Theoretical Computer Science, 2011 In this paper we study generalization of the reversal mapping realized by an arbitrary involutory antimorphism $ $. It generalizes the notion of a palindrome into a $ $-palindrome -- a word invariant under $ $. For languages closed under $ $ we give the relation between $ $-palindromic complexity and factor complexity.
openaire +3 more sources
ChemistryEurope, EarlyView.Larger‐scale enzymatic synthesis of base‐modified DNA is developed using primer extension with KOD(exo‐) DNA polymerase allowing preparation of milligram amounts of the modified DNA sufficient for NMR structural analysis. Milligram (≈200 nmol) scale enzymatic synthesis of base‐modified DNA is developed based on primer extension using easily accessible ...
Veronika Raindlová +6 more
wiley +1 more source
Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics
Clinical Pharmacology &Therapeutics, EarlyView.The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou +6 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu +9 more
wiley +1 more source
Narrow sieves for parameterized paths and packings
, 2010 We present randomized algorithms for some well-studied, hard combinatorial problems: the k-path problem, the p-packing of q-sets problem, and the q-dimensional p-matching problem.
Björklund, Andreas +3 more
core