Progress in RNA‐Targeted Therapeutics for Human Diseases
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang +10 more
wiley +1 more source
Jade1 and the HBO1 histone acetyltransferase complex are spatial-selective cofactors of the pluripotency transcription factor Oct4. [PDF]
Wu Y +6 more
europepmc +1 more source
Scalable spokes pTx pulses for 2D turbo‐spin‐echo imaging at 7 T
Abstract Purpose Turbo spin echo (TSE) is important clinically. Unfortunately, 7 T TSE suffers from B1+‐induced signal dropouts. Magnitude‐based parallel transmit (pTx) pulse design algorithms cannot enforce phase patterns complying with the Carr‐Purcell‐Meiboom‐Gill conditions (90° phase shift between excitation and refocusing).
Minghao Zhang, Christopher T. Rodgers
wiley +1 more source
This Mendelian randomization study provides genetic evidence supporting a causal effect of rheumatoid arthritis on the risk of interstitial lung disease, highlighting potential shared mechanisms between autoimmune arthritis and pulmonary fibrosis. ABSTRACT Background and Objectives Rheumatoid arthritis (RA) is a systemic autoimmune disease that is ...
Mengyu Zhang +5 more
wiley +1 more source
Structural characterization of the HDV virion and its ribonucleoprotein. [PDF]
Itskanov S +8 more
europepmc +1 more source
Refined chloroplast annotations, repeat profiles, and phylogenomic evidence reveal maternal lineage shifts and independent evolution in the Triticum-Aegilops complex. [PDF]
Kadam SK, Yun JS, Kim JH.
europepmc +1 more source
Genomic Insights into Ceftazidime Resistance in Burkholderia pseudomallei : Discovery of A172T Mutation, and Palindromic GC-Rich Repeat Sequences Facilitating penA Duplication and Amplification. [PDF]
Apichai Tuanyok +13 more
openalex +1 more source
Mirror-synchronized asymmetric CRISPR nanoswitch for single-molecule profiling of multiple circRNAs in different stages of breast cancer. [PDF]
Liu Q, Pan TT, Wang LJ, Zhang CY.
europepmc +1 more source
Palindromic properties of infinite sequences with applications to Number Theory
Amy Glen
openalex +1 more source

