Results 241 to 250 of about 80,959 (317)

Advances in the Development of Lipid Nanoparticles for mRNA Delivery

Small Structures, Volume 7, Issue 2, February 2026.
This review provides an integrated overview of mRNA–lipid nanoparticle (LNP) design, including lipid composition, scalable manufacturing, and structure–activity relationships. We highlight strategies for targeted delivery, physicochemical tuning, and high‐throughput screening such as DNA barcoding.
Xing Wang, Letao Xu, Zhenwei Lan, Yue Hui, Yun Liu, Guangze Yang, Chun‐Xia Zhao   +6 more
wiley   +1 more source

Dissecting cellular ecosystem with single-cell CRISPR screens. [PDF]

Blood Sci
Liu Z, Lan Z, Kang X, Yao Y, Rao S.
europepmc   +1 more source

Targeting Overexpressed IDO in Stromal Cells as a Potential Therapeutic Strategy in Multiple Myeloma

Cancer Science, Volume 117, Issue 2, Page 325-334, February 2026.
IDO expression in stromal cells was upregulated by MM cells via the JAK–STAT1–NF‐κB–IRF1 signaling pathway. JAK inhibitor abolished IDO and IRF1 upregulation. ABSTRACT Stromal cells are an essential component of the tumor microenvironment (TME) in multiple myeloma (MM). Indoleamine 2,3‐dioxygenase 1 (IDO), an enzyme that metabolizes tryptophan (Trp) to
Toru Ebina, Masaki Ri, Yoshiaki Marumo, Tomoyuki Nakamura, Hirokazu Sasaki, Yoshiko Oshima, Takahiro Nakashima, Shinya Hagiwara, Arisa Asano, Shiori Kinoshita, Tomotaka Suzuki, Tomoko Narita, Ayako Masaki, Takaomi Sanda, Kazufumi Yamagata, Kohmei Kubo, Hirokazu Komatsu, Hirotake Sakuraba, Shinsuke Iida   +18 more
wiley   +1 more source

CRISPR‐Cas9 screen reveals that inhibition of enhancer of zeste homolog 2 sensitizes malignant T cells to dimethyl‐fumarate‐induced cell death

The FEBS Journal, Volume 293, Issue 3, Page 749-765, February 2026.
A genome‐wide CRISPR‐Cas9 screen identified H3K27 methylation as a key regulator of T‐cell lymphoma sensitivity to dimethyl fumarate (DMF). Specifically, inhibition of enhancer of zeste homolog 2 (EZH2) enhanced DMF‐induced cell death in malignant T cells. These results provide functional evidence for the role of EZH2 in modulating drug sensitivity and
Jan P. Teubner, Deniz Tümen, Arne Kandulski, Philipp Heumann, Patricia Mester, Elisabeth Aschenbrenner, Kirstin Pollinger, Manuela Gunckel, Barbara Volz, Tobias Hein, Paul L. Beltzig, Luisa Tengler, Florian Voll, Marina Kreutz, Claudia Kunst, Jan P. Nicolay, Martina Müller, Karsten Gülow   +17 more
wiley   +1 more source

Comparative analysis of mitochondrial genomes of <i>Epimedium</i> L. reveals heterogeneity in structure, synteny, intercellular gene transfer, and RNA editing. [PDF]

Front Plant Sci
Xu, Huang J, Ma Q, Wang T, Zhang Z, Wang Q, Wang Z, Xie Z, Liu X, Fu L.   +9 more
europepmc   +1 more source

Light regulates tomato fruit metabolome via SlDML2‐mediated global DNA demethylation

Journal of Integrative Plant Biology, Volume 68, Issue 2, Page 383-405, February 2026.
In tomato growth and development, red and blue light signals are captured by the photoreceptors phyB2 and CRY1a, which kickstart tomato fruit ripening by activating HY5, which activates DNA demethylation via DML2 to trigger a metabolic and ripening transformation cascade within the tomato.
Zixin Zhang, Jing Zhang, Yi Wang, Yuting Chen, Qian Hu, Xin Zhang, Wen Li, Yiren Xiao, Ke Zhou, Yanling Lai, Dan Su, Evangelos Tatsis, Gaofeng Liu, Mingchun Liu, Zhenhui Zhong, Yang Zhang   +15 more
wiley   +1 more source

Characteristics and Phylogenetic Analysis of the Complete Chloroplast Genome of <i>Abelmoschus esculentus</i>. [PDF]

Int J Mol Sci
Dong J, Du G, Ji Q, An X, Zhu Z, Tang S, Luo X, Chen C, Liu T, Zou L, Li S, Chen J, An X.   +12 more
europepmc   +1 more source

A single‐MYB transcription factor GmMYB331 regulates seed oil accumulation and seed size/weight in soybean

Journal of Integrative Plant Biology, Volume 68, Issue 2, Page 470-485, February 2026.
The soybean transcription factor GmMYB331 regulates oil content and seed size. Moderate expression of GmMYB331 significantly enhanced seed oil accumulation, and strong expression promoted increased seed size. This research provides a genetic resource and theoretical foundation for high‐yield and quality breeding in soybean.
Zhou‐Ya Wang, Lu‐Yao Zhang, Bin Zhou, Jing‐Jing Liang, Yan‐Bao Tian, Zhi‐Hao Jiang, Jian‐Jun Tao, Cui‐Cui Yin, Shou‐Yi Chen, Wan‐Ke Zhang, Jin‐Song Zhang, Wei Wei   +11 more
wiley   +1 more source

The Complete Mitochondrial Genome of the Dioscorea opposita Thunb. cv. Tiegun, a Traditional Medicinal and Edible Crop. [PDF]

Biology (Basel)
Zhu D, Feng F, Shi X, Tian M, Chen Z, Zhang J.   +5 more
europepmc   +1 more source

The frequency and importance of polyploidy in tropical rainforest tree radiations

New Phytologist, Volume 249, Issue 4, Page 2103-2114, February 2026.
Summary The presence of more than two copies of the genome in an organism, termed ‘polyploidy’, is a crucial force in plant evolution, generating genetic, phenotypic and ecological diversity. [Correction added on 22 January 2026, after first online publication: the preceding sentence has been corrected.] The Amazonian tree flora is the most species ...
Rowan J. Schley, Rosalía Piñeiro, James A. Nicholls, Michelle L. Gaynor, Gwilym P. Lewis, Flávia Fonseca Pezzini, Kyle G. Dexter, Catherine Kidner, R. Toby Pennington, Alex D. Twyford   +9 more
wiley   +1 more source