Results 31 to 40 of about 2,776,901 (186)

Over two decades of research on the marine RNA virosphere

iMeta, Volume 1, Issue 4, December 2022., 2022
Advances in meta‐omics provide a surge of marine RNA virus information. Deep marine virus discovery contributes greatly to the megataxonomy of RNA viruses. Understanding diversity and biogeography helps reveal the significance of marine RNA viruses, including evolutionary trajectories, hierarchical taxonomy, and ecological importance.
Meng‐en Liao, Yunyi Xie, Mang Shi, Jie Cui   +3 more
wiley   +1 more source

Stimulation of human papillomavirus type 1a DNA replication by a multimerized AT-rich palindromic sequence.

Virology, 1995
Replication of most papillomaviruses requires the viral E1 and E2 proteins and an origin of replication containing the E1 and E2 binding sites. In the case of human papillomavirus type 1a (HPV-1a), the E1 protein alone is sufficient for DNA replication ...
V. Gopalakrishnan, S. Walker, S. Khan
semanticscholar   +1 more source

Identification of a Palindromic Sequence That Is Responsible for the Up-regulation of NAPDH-Ferredoxin Reductase in a Ferredoxin I Deletion Strain of Azotobacter vinelandii *

Journal of Biological Chemistry, 1997
Azotobacter vinelandii ferredoxin I (AvFdI) is one member of a class of 7Fe ferredoxins found in a variety of organisms that are all capable of aerobic growth. Disruption of the fdxA gene, which encodesAvFdI, leads to overexpression of its redox partner,
S. Yannone, B. Burgess
semanticscholar   +1 more source

Framework nucleic acids directed assembly of Au nanostructures for biomedical applications

Interdisciplinary Medicine, Volume 1, Issue 1, January 2023., 2023
This Review article discusses the advanced progress in the Au and DNA nanomaterials. Introduced by the latest advances in frame nucleic acids‐detected Au nanostructures, the biomedical applications including biosensing and therapeutics are explored.
Bing Liu, Zhonglin Qi, Jie Chao
wiley   +1 more source

Amplification‐Free, Sequencing‐Free, Detection of Viral RNAs with Variant Specification by Discrete Nanocounting

Advanced Functional Materials, EarlyView.
Integrating selective RNA shortcut, targeted gene isolation, and micro‐arrayed nanoimaging, the NanoPick‐array platform excels in detecting severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) at just 60 copies µL−1 and accurately differentiating variants at the single‐nucleotide level. It ensures 100% accuracy for samples with cycle threshold (
Zixun Wang, Xi Zhao, Wan‐Mui Chan, Xianglin Ji, Linfeng Huang, Xi Xie, Wei Li, Wenjun Zhang, Kelvin Kai‐Wang To, Peng Shi   +9 more
wiley   +1 more source

Nucleic acid nanostructure for delivery of CRISPR/Cas9‐based gene editing system

Interdisciplinary Medicine, Volume 1, Issue 1, January 2023., 2023
Multifunctional nucleic acid nanostructures, including RCA‐derived DNA, branched DNA, and hybrid DNA, have been developed for delivery of CRISPR/Cas9‐based gene editing system for gene therapy. Abstract CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR‐associated protein 9)‐based gene editing system has aroused great ...
Wantao Tang, Jianbing Liu, Baoquan Ding
wiley   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

A dual-function palindromic sequence regulates testis-specific transcription of the mouse lactate dehydrogenase c gene in vitro.

Biology of Reproduction, 1996
The promoter of the mouse lactate dehydrogenase c (Ldh-c) gene was assayed in an in vitro transcription system. Of the nuclear extracts isolated from several mouse tissues, only testis supported transcription from a 710 Ldh-c promoter fragment.
W. Zhou, E. Goldberg
semanticscholar   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Evaporation‐Enhanced Redox Cycling for Rapid Detection of Attomolar SARS‐CoV‐2 Virions Using Nanolithography‐Free Electrochemical Devices

Advanced Materials Technologies, EarlyView.
This study presents microfabricated electrochemical sensors for detecting ultralow viral particles counts through evaporation‐enhanced redox cycling (E2RC). To achieve sub‐micrometer gap in interdigitated microelectrodes, a scalable, nanolithography‐free fabrication method is developed.
Pouya Soltan Khamsi, Vinay Kammarchedu, Aida Ebrahimi   +2 more
wiley   +1 more source