Results 61 to 70 of about 2,776,901 (186)

Synergistic bactericide and antibiotic effects of dimeric, tetrameric, or palindromic peptides containing the RWQWR motif against Gram-positive and Gram-negative strains

RSC Advances, 2019
Dimeric and tetrameric peptides derived from LfcinB (20–25): RRWQWR, LfcinB (20–30): RRWQWRMKKLG, LfcinB (17–31): FKARRWQWRMKKLGA, or the palindromic sequence LfcinB (21–25)Pal: RWQWRWQWR were obtained by means of the SPPS-Fmoc/tBu methodology.
Yerly Vargas-Casanova, A. Rodríguez-Mayor, Karen Cárdenas, A. Leal‐Castro, Liliana Constanza Muñoz-Molina, Ricardo Fierro-Medina, Z. Rivera-Monroy, J. García-Castañeda   +7 more
semanticscholar   +1 more source

Genomic Insights Into a Strong Biofilm‐Forming Enterococcus faecalis MTR_EFS01 Strain Isolated From a Shrimp in Bangladesh

Animal Research and One Health, EarlyView.
This study characterizes a multidrug‐resistant and strong biofilm‐forming Enterococcus faecalis strain obtained from a shrimp sample in Bangladesh. ABSTRACT Enterococcus faecalis is known for its ability to form strong biofilms and its role as an opportunistic pathogen. In this study, we screened and characterized a multidrug‐resistant (MDR) and strong
Md. Ashek Ullah, Md. Saiful Islam, Md. Liton Rana, Jayedul Hassan, Md. Tanvir Rahman   +4 more
wiley   +1 more source

History of CRISPR-Cas from Encounter with a Mysterious Repeated Sequence to Genome Editing Technology

Journal of Bacteriology, 2018
Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas systems are well-known acquired immunity systems that are widespread in archaea and bacteria.
Y. Ishino, M. Krupovic, P. Forterre
semanticscholar   +1 more source

Honey Bee Breeding and Breed: Advancements, Challenges, and Prospects

Animal Research and One Health, EarlyView.
Our work clarifies concepts related to honey bee classification, reviews traditional and modern breeding techniques, explores advancements in molecular breeding, prospects gene‐editing tools, and advocates for integrated breeding strategies to ensure the long‐term sustainability and vitality of honey bee populations amid declining managed populations ...
Zheguang Lin, Lizhi Yang, Zhi Wang, Kang Wang, Qingsheng Niu, Ting Ji   +5 more
wiley   +1 more source

A Novel Family of Sequence-specific Endoribonucleases Associated with the Clustered Regularly Interspaced Short Palindromic Repeats*

Journal of Biological Chemistry, 2008
Clustered regularly interspaced short palindromic repeats (CRISPRs) together with the associated CAS proteins protect microbial cells from invasion by foreign genetic elements using presently unknown molecular mechanisms.
N. Beloglazova, Greg Brown, M. Zimmerman, Michael Proudfoot, K. Makarova, M. Kudritska, Samvel Kochinyan, Shuren Wang, M. Chruszcz, W. Minor, E. Koonin, A. Edwards, A. Savchenko, A. Yakunin   +13 more
semanticscholar   +1 more source

Engineering an Overflow‐Responsive Regulation System for Balancing Cellular Redox and Optimizing Microbial Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Escherichia coli accumulates acetate as a byproduct in fast growth aerobic conditions when using glucose as carbon source. This phenomenon, known as overflow metabolism, has negative impacts on cell growth and protein expression, also causes carbon loss during biosynthesis in most microbial production scenarios. In this study, we regarded the “
Jianli Zhang, Jian Wang, Tian Jiang, Xinyu Gong, Qi Gan, Yuxi Teng, Yusong Zou, Ainoor Anwar Dawadi, Yajun Yan   +8 more
wiley   +1 more source

Advances in Isotope Labeling for Solution Nucleic Acid NMR Spectroscopy

ChemPlusChem, Accepted Article.
The availability of nucleic acid structural biology methods still lags behind that of proteins, as evidenced by the significantly smaller number of structures deposited in the PDB. The highly skewed ratio of nucleic acid structures, relative to their protein counterparts (~1:50), is inverted with respect to the cellular output of RNA and proteins in ...
Stefan Hilber, Solomon Kojo Attionu, Theodore Kwaku Dayie, Christoph Kreutz   +3 more
wiley   +1 more source

Sequence analysis of deletion mutations at the HPRT locus of human T-lymphocytes: association of a palindromic structure with a breakpoint cluster in exon 2.

Mutagenesis, 1996
To study the structure and mechanism of deletion mutation in human somatic cells in vivo, we have identified and sequenced the breakpoints of 16 independent deletions at the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus in human T ...
A. Osterholm, T. Bastlová, A. Meijer, A. Podlutsky, N. Zanesi, S. Hou   +5 more
semanticscholar   +1 more source

Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics

Clinical Pharmacology &Therapeutics, EarlyView.
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou, Rohit Rao, Monica E. Shapiro, Nessy Tania, Cody Herron, Cynthia J. Musante, Jim H. Hughes   +6 more
wiley   +1 more source

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

Drug Testing and Analysis, EarlyView.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis, Tiia  Kuuranne, Hans  Geyer   +2 more
wiley   +1 more source