Results 111 to 120 of about 505,011 (403)

Palladium and Nickel Catalyzed Chain Walking Olefin Polymerization and Copolymerization

, 2016
In this perspective, recent developments on palladium and nickel mediated chain walking olefin polymerization and copolymerization with polar functionalized comonomers are described. First, the chain walking polymerization mechanism is discussed followed
Lihua Guo, Shengyu Dai, Xuelin Sui, Changle Chen   +3 more
semanticscholar   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Anionic Palladium(0) and Palladium(II) Ate Complexes

Angewandte Chemie International Edition, 2017
AbstractPalladium ate complexes are frequently invoked as important intermediates in Heck and cross‐coupling reactions, but so far have largely eluded characterization at the molecular level. Here, we use electrospray‐ionization mass spectrometry, electrical conductivity measurements, and NMR spectroscopy to show that the electron‐poor catalyst [L3Pd] (
Marlene Kolter, Katharina Böck, Konstantin Karaghiosoff, Konrad Koszinowski   +3 more
openaire   +4 more sources

Regioselective zincation of indazoles using TMP2Zn and Negishi cross-coupling with aryl and heteroaryl iodides. [PDF]

, 2012
The metalation of various SEM-protected functionalized indazoles with TMP2Zn provides 3-zincated indazoles which undergo palladium-catalyzed Negishi cross-couplings in good ...
Andreas Unsinn, Batt, Bunnell, Bunnell, Chevallier, Clutterbuck, Collot, Crestey, Despotopoulou, Dong, Dunst, Farina, Fraile, Haag, Haag, Kienle, Knochel, Luo, Malamas, Mulvey, Negishi, Negishi, Negishi, Negishi, Negishi, Ohnmacht, Pabba, Paul Knochel, Perez, Peruncheralathan, Piazza, Pyne, Schmidt, Stadlbauer, Sun, Villieras, Welch, Whisler, Wunderlich, Wunderlich, Yang   +40 more
core   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Reactivity of metallic palladium in a K2CO3-K2O-B2O3-Al2O3 melt

Results in Chemistry, 2020
The reactivity of metallic palladium in a K2CO3-K2O-B2O3 melt is investigated as a function of heating temperature and time. The aqueous solubility of heat-treated palladium is enhanced by controlling the heating conditions leading to an optimum ...
Takashi Okada, Fumihiro Nishimura, Susumu Yonezawa   +2 more
doaj  

New insights into the chemistry of thiolate-protected palladium nanoparticles [PDF]

, 2012
This paper establishes the chemical nature of Pd nanoparticles protected by alkanethiolates that were prepared through a ligand place-exchange approach and the two-phase method, first developed for Au nanoparticles by Brust and Schiffrin.
Amaya, Edgar Gilberto, Benitez, Guillermo Alfredo, Corthey, Gastón, Fonticelli, Mariano Hernan, Giovanetti, Lisandro Jose, Picone, Andrea Lorena, Ramallo Lopez, Jose Martin, Requejo, Felix Gregorio, Rubert, Aldo Alberto, Salvarezza, Roberto Carlos, Yacamán, Miguel Jose, Zelaya, Maria Eugenia   +11 more
core   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

A Universal Live Cell Barcoding-Platform for Multiplexed Human Single Cell Analysis. [PDF]

, 2018
Single-cell barcoding enables the combined processing and acquisition of multiple individual samples as one. This maximizes assay efficiency and eliminates technical variability in both sample preparation and analysis.
Bendall, Sean C, Hartmann, Felix J, Simonds, Erin F   +2 more
core  

A detailed study of the diastereoselective catalytic hydrogenation of 6-hydroxytetrahydroisoquinoline-(3R)-carboxylic ester intermediates [PDF]

, 2012
A key step towards a highly-selective antagonist of ionotropic glutamate receptors entails the diastereoselective arene hydrogenation of an enantiopure tetrahydroisoquinoline.
Ager, David J.,, Argentine, Mark D.,, Fennell, Jared W.,, Lefort, Laurent,, Maloney, Todd D.,, Scherer, Roger B.,, Sereinig, Natascha,, Straatman, Harrie,, Sullivan, Kevin A.,, Vries, Johannes G. de,, Werner, John A.,   +10 more
core   +1 more source