Results 51 to 60 of about 241,973 (264)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Total Iliocaval Reconstruction in a Complex Palliative Patient with Malignant Inferior Vena Cava Syndrome

Current Oncology
Inferior vena cava (IVC) compression secondary to mass effect is accompanied by edema, ascites, back and abdominal pain, and central nervous system symptoms. Most IVC syndrome cases described in the literature focus on the focal treatment of IVC lesions,
Jack Lofroth, Amir Pourghadiri, Anastasia Hadjivassiliou, Manraj Heran, Gerald Legiehn, Stephen Ho, Ravjot Dhatt   +6 more
doaj   +1 more source

Counselling the terminally ill — Can we prepare for death?

South African Family Practice, 2006
The family medical practitioner is a key player when care of the patient becomes palliative. The practitioner's ability to be present to the psychological, spiritual and social needs—in addition to the physical -gives reassurance and affirmation of life ...
S. Nieuwmeyer, M. Hosking
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Editorial: Emergency medicine in pediatric patients with chronic diseases

Frontiers in Pediatrics, 2023
Emmanuel Schneck, Johannes Wolff, Jan-Thorsten Graesner, Holger Hauch   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Effects of escitalopram in depressed elderly patients with cancer receiving palliative care in Ain Shams University Hospitals

Palliative Medicine in Practice
BACKGROUND: The prevalence of depressive disorders among patients with cancer is greater than that of the general population, especially in the geriatric population, and is associated with less compliance to anti-cancer treatment, an increase in the ...
Sara Farrag Mohamed Gharib, Hala Samir Sweed, Lamiaa Moustafa Ahmed, Amal Emam Emam, Elham Arif   +4 more
doaj   +1 more source

Symptom Burden and Palliative Referral Disparities in an Ambulatory South Texas Cancer Center

Frontiers in Oncology, 2018
Background: The American Society of Clinical Oncology's recommendation for “dedicated palliative care services, early in the disease course, concurrent with active treatment” for cancer patients is a challenge for cancer centers to accommodate.
Sherri Rauenzahn Cervantez, Laura L. Tenner, Susanne Schmidt, Ifeoma O. Aduba, Jessica T. Jones, Nazneen Ali, Savitri Singh-Carlson   +6 more
doaj   +1 more source

Stereotactic Cavity Irradiation or Whole-Brain Radiotherapy Following Brain Metastases Resection—Outcome, Prognostic Factors, and Recurrence Patterns

Frontiers in Oncology, 2020
Introduction: Following the resection of brain metastases (BM), whole-brain radiotherapy (WBRT) is a long-established standard of care. Its position was recently challenged by the less toxic single-session radiosurgery (SRS) or fractionated stereotactic ...
Rami A. El Shafie, Rami A. El Shafie, Rami A. El Shafie, Thorsten Dresel, Thorsten Dresel, Dorothea Weber, Daniela Schmitt, Daniela Schmitt, Kristin Lang, Kristin Lang, Kristin Lang, Laila König, Laila König, Laila König, Simon Höne, Simon Höne, Simon Höne, Tobias Forster, Tobias Forster, Tobias Forster, Bastian von Nettelbladt, Bastian von Nettelbladt, Bastian von Nettelbladt, Tanja Eichkorn, Tanja Eichkorn, Tanja Eichkorn, Sebastian Adeberg, Sebastian Adeberg, Sebastian Adeberg, Jürgen Debus, Jürgen Debus, Jürgen Debus, Jürgen Debus, Jürgen Debus, Jürgen Debus, Stefan Rieken, Stefan Rieken, Stefan Rieken, Stefan Rieken, Denise Bernhardt, Denise Bernhardt, Denise Bernhardt   +41 more
doaj   +1 more source