Results 61 to 70 of about 241,973 (264)

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

First palliation for the fragile: Short-term outcomes of ductal stenting versus surgical shunt in small infants with restricted pulmonary blood flow

Annals of Pediatric Cardiology
Background: In congenital heart disease (CHD) with restricted pulmonary blood flow, infants require urgent palliation, either with a modified Blalock–Taussig–Thomas (m-BTT) shunt or ductal stenting.
Olfi Lelya, Alesia Prillya Mauna, Michael Sugiyanto, Sisca Natalia Siagian, Yovi Kurniawati, Oktavia Lilyasari, Aditya Agita Sembiring, Damba Dwisepto Aulia Sakti, Indriwanto Sakidjan Atmosudigdo, Rissa Ummy Setiani, Radityo Prakoso   +10 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Interprofessional Clinician Perspectives on Goals-of-Care Communication During Chronic Critical IllnessTake-Home Points

CHEST Critical Care
Background: Patients with chronic critical illness (CCI) experience prolonged mechanical ventilation, severe symptoms, poor quality of life, and low survival.
Katherine H. Walker, MD, Valencia Lambert, MS, Emanuele Mazzola, PhD, Alexa DiPalma, SLP, Emily B. Rubin, MD, Isaac S. Chua, MD, MPH, James A. Tulsky, MD, Joshua R. Lakin, MD   +7 more
doaj   +1 more source

Palliative, palliative or palliative?

, 2020
Palliative care is a necessary and often essential component in the medical journey of some patients. They can intervene at all stages of a severe chronic disease and their need grows as it progresses. While the strategy and the therapeutic intensity differ depending on this development, the only term "palliative" is used.
openaire   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Chemotherapy Regimens and Survival in Pancreatic Cancer—A Ten‐Year Single Centre Overview

Cancer Medicine
Background During the last decade chemotherapy recommendations have changed for patients with pancreatic adenocarcinoma (PDAC) as novel regimens demonstrate better survival in selected cohorts.
Hedda Tranvik, Farima Brandt, Caroline Williamsson, Hanna Sternby   +3 more
doaj   +1 more source

Palliative Management of Advanced Pancreatic Cancer: The Role of Gastroentero-hepatologist

Acta Medica Indonesiana, 2020
Pancreatic cancer commonly diagnosed at late stage due to subtle clinical manifestation and associated with low 5-year survival rate. Only 10-20% of patients were found in resectable or localized stage.
Randy Adiwinata, Andrea Livina, Bradley Jimmy Waleleng, Nelly Tendean, Fandy Gosal, Luciana Rotty, Jeanne Winarta, Andrew Waleleng   +7 more
doaj  

Palliative and End of Life Care for Neonates [PDF]

Iranian Journal of Neonatology
Palliative care is an interdisciplinary approach to improves the quality of life of patients and their families who are facing challenges associated with life-threatening illness, whether physical, psychological, social or spiritual.
Reza Saeidi
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source