Results 131 to 140 of about 150,427 (264)

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Palliative Medicine Point of Care UltraSound in Cancer Patients in a Specialist Palliative Medicine Outpatient Department: A Retrospective Analysis of Diagnostic and Procedural Impact. [PDF]

Indian J Palliat Care
Thota RS, Poojary S, Deodhar J, Shah IJ, Kamble S, Ajithkumar A, Varun TM, Gunde S, Bhagat P.   +8 more
europepmc   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Adapting and implementing the Serious Illness Care Programme for outpatient oncology, cardiology and palliative medicine clinics: a mixed-methods feasibility study. [PDF]

BMJ Open
Ng A, Yeo SM, Neo SH.
europepmc   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

Palliative medicine physicians' experiences using the Numeric Rating Scale for pain assessment in patients with advanced cancer: a qualitative study. [PDF]

BMJ Open
Martinsson L, Brännström M, Fransson P, Andersson S.   +3 more
europepmc   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Emergency Physicians and Hospice and Palliative Medicine: A Growing Trend in Fellowship Training. [PDF]

J Pain Symptom Manage
Zirulnik A, Meehan C, Markwalter D, Gabbard J, Tilly A, Zimmerman P, Stafford J, Brooten J.   +7 more
europepmc   +1 more source

Factors Influencing Mechanical Ventilation and Inpatient Palliative Care Utilization in Patients With Chronic Obstructive Pulmonary Disease

Journal of Multidisciplinary Healthcare
Li-Ting Kao,1,* Chun-Chieh Yang,2,* Yu-Cih Wu,3 Shian-Chin Ko,4 Yi-Shan Liang,1 Kuang-Ming Liao,5,6 Chung-Han Ho3,7,8 1Department of Respiratory Therapy, Chi-Mei Medical Center, Tainan, Taiwan; 2Department of Intensive Care Medicine, Chi-Mei ...
Kao LT, Yang CC, Wu YC, Ko SC, Liang YS, Liao KM, Ho CH   +6 more
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