Results 101 to 110 of about 7,263 (276)

Bayesian Population Pharmacokinetic Modeling of Ondansetron for Neonatal Opioid Withdrawal Syndrome

Clinical and Translational Science, Volume 18, Issue 2, February 2025.
ABSTRACT Ondansetron is an anti‐emetic 5‐HT3 receptor antagonist being investigated for treating neonatal opioid withdrawal syndrome (NOWS). Sparse PK data were analyzed from a multicenter, double‐blind clinical trial with 98 mother/neonate dyads. Pregnant women with opioid use disorder were randomized to receive either placebo or ondansetron 8 mg ...
Kevin Lam, John T. Mondick, Gary Peltz, Manhong Wu, Walter K. Kraft   +4 more
wiley   +1 more source

Intravenous palonosetron increases the incidence of QTc prolongation during sevoflurane general anesthesia for laparotomy [PDF]

Korean Journal of Anesthesiology, 2013
BackgroundPalonosetron is a recently introduced 5-hydroxytryptamine-3 (5-HT3) receptor antagonist useful for postoperative nausea and vomiting prophylaxis.
Jeong Jin Min, Yongjae Yoo, Tae Kyong Kim, Jung-Man Lee   +3 more
doaj   +1 more source

The final transformation of Étaín [PDF]

, 2016
Background Although serotonin (5-HT3) receptor antagonists are effective in reducing nausea and vomiting, they may be associated with increased cardiac risk.
Antony, Jesmin, Ashoor, Huda, Blondal, Erik, Cardoso, Roberta, Hemmelgarn, Brenda R, Ho, Joanne, Ivory, John, Johnson, Christy, Lillie, Erin, Ng, Carmen, Nincic, Vera, Reynen, Emily, Roberts, Derek J, Soobiah, Charlene, Straus, Sharon E, Strifler, Lisa, Tricco, Andrea C, Vafaei, Afshin, Veroniki, Areti A   +18 more
core   +3 more sources

Data‐driven discovery of associations between prescribed drugs and dementia risk: A systematic review

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 11, Issue 1, January-March 2025.
Abstract Recent clinical trials on slowing dementia progression have led to renewed focus on finding safer, more effective treatments. One approach to identify plausible candidates is to assess whether existing medications for other conditions may affect dementia risk. We conducted a systematic review to identify studies adopting a data‐driven approach
Benjamin R. Underwood, Ilianna Lourida, Jessica Gong, Stefano Tamburin, Eugene Yee Hing Tang, Emad Sidhom, Xin You Tai, Matthew J. Betts, Janice M. Ranson, Margarita Zachariou, Olajide E. Olaleye, Saswati Das, Neil P. Oxtoby, Shanquan Chen, David J. Llewellyn, for the Deep Dementia Phenotyping (DEMON) Network   +15 more
wiley   +1 more source

Comparison of Antiemetic Effectiveness of Palonosetron Versus Ondansetron in Patients on Cancer Chemotherapy: A Prospective Observational Study in South Indians [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Chemotherapy Induced Nausea and Vomiting (CINV) is the most distressing side effect of cancer chemotherapy. It can seriously produce an impact on patient's quality of life.
Abdul Aslam Parathoduvil, Asha Sisupalan, Padanayil Lekshmikutty Rema   +2 more
doaj   +1 more source

Pre-therapy mRNA expression of TNF is associated with regimen-related gastrointestinal toxicity in patients with esophageal cancer: a pilot study [PDF]

, 2015
Author version made available following 12 month embargo from date of publication (27 March 2015) in accordance with publisher copyright policy.Purpose Esophageal cancer has a high mortality rate, and its multimodality treatment is often associated ...
Bowen, Joanne M, Game, Philip A, Hussey, Damian James, Irvine, Tanya S, Karapetis, Christos Stelios, Keefe, Dorothy M K, Kristaly, Kerry, Smith, Lorelle T, Tan, Thean Hsiang, Thompson, Sarah K, Tsykin, Anna, Watson, David Ian, White, Ian   +12 more
core   +1 more source

Palonosetron in pediatric patients: A single-center, retrospective evaluation of policy and clinical practice guideline discordance

Journal of Oncology Pharmacy Practice
Introduction Clinical practice guidelines (CPGs) recommending palonosetron for the prevention and management of chemotherapy-induced nausea and vomiting (CINV) were adapted for use at our institution.
Meredith Ames, P. Patel, L. Dupuis, Alicia Koo   +3 more
semanticscholar   +1 more source

Predicting Drug Targets in Human Cancers

Journal of Clinical Pharmacy and Therapeutics, Volume 2025, Issue 1, 2025.
Introduction A large amount of knowledge has accumulated regarding the pharmacology of most cancer types, including their side effects, and during the last decade, many novel agents have emerged, accompanied by increased costs for healthcare systems. Aim Artificial intelligence (AI) was applied in healthcare services, and the benefit of its use in the ...
David Calderón Guzmán, Norma Osnaya Brizuela, Armando Valenzuela Peraza, Maribel Ortiz Herrera, Diego E. Ortega Garcia, Hugo Juarez Olguin, Gerardo Barragán Mejía, Md Saquib Hasnain   +7 more
wiley   +1 more source

Efficacy of the combination use of aprepitant and palonosetron for improving nausea in various moderately emetogenic chemotherapy regimens

BMC Pharmacology and Toxicology, 2019
Background Nausea is more difficult to control than vomiting in chemotherapy. We therefore analyzed the efficacy of a strong supportive treatment with aprepitant, palonosetron, and dexamethasone against nausea for various moderately emetogenic ...
Naohisa Yoshida, Tetsuya Taguchi, Masayoshi Nakanishi, Ken Inoue, Tetsuya Okayama, Takeshi Ishikawa, Eigo Otsuji, Koichi Takayama, Haruo Kuroboshi, Motohiro Kanazawa, Yoshito Itoh   +10 more
doaj   +1 more source

Epidemiology and treatment for thyroid cancer [PDF]

, 2011
The thyroid gland produces thyroid hormones which are important in the normal regulation of the metabolism of the body. Thyroid cancer is the most common malignancy of the endocrine system consisting of several subtypes like papillary carcinoma, and ...
Hima Bindu, A., Soumya, D., Srilatha, B.
core   +1 more source