Results 81 to 90 of about 2,968 (201)

Effects of palonosetron for prophylaxis of postoperative nausea and vomiting in high-risk patients undergoing total knee arthroplasty: A prospective, randomized, double-blind, placebo-controlled study.

PLoS ONE, 2018
BackgroundThe preemptive multimodal pain protocols used in total knee arthroplasty (TKA) often cause emesis postoperatively. We investigated whether palonosetron prophylaxis reduces postoperative nausea and vomiting (PONV) in high-risk patients after TKA.
Jung-Hee Ryu, Young-Tae Jeon, Byunghun Min, Jin-Young Hwang, Hye-Min Sohn   +4 more
doaj   +1 more source

Palonosetron Hydrochloride in the Prevention and Treatment of Postoperative Nausea and Vomiting

, 2010
On the strength of two phase III clinical trials, palonosetron hydrochloride was granted FDA approval in March 2008 for the prevention of postoperative nausea and vomiting (PONV) in the period up to 24 hours after surgery. Palonosetron is superior to the
Peter Kranke, Jan Wallenborn
core   +1 more source

Palonosetron versus ondansetron for prophylaxis of postoperative nausea and vomiting in laparoscopic cholecystectomy: a non-inferiority randomized controlled trial

Brazilian Journal of Anesthesiology
Background: We tested the hypothesis that, within the margin of 15% of risk difference, palonosetron is not inferior to ondansetron in reducing the incidence of postoperative nausea and vomiting (PONV) in laparoscopic cholecystectomy.
Francisco Jos.. Chiaradia Davolos, Norma S. Modolo, Leandro G. Braz, Paulo do Nascimento Junior   +3 more
doaj   +1 more source

Effect of intravenous palonosetron on hypotension induced by spinal anesthesia for cesarean section: A randomized controlled trial.

PLoS ONE
BackgroundThe aim of this study was to evaluate the impact of intravenous palonosetron compared to ondansetron on hypotension induced by spinal anesthesia in women undergoing cesarean section.MethodsFifty-four women scheduled for elective cesarean ...
Min Kyoung Kim, Injeong Kim, Hyun Kang, Wongook Wi, Yong Hee Park, Yong Hun Jung, Young Cheol Woo, Chong Wha Baek   +7 more
doaj   +1 more source

Comparison of efficacy and safety between palonosetron and ondansetron to prevent postoperative nausea and vomiting in patients undergoing laparoscopic surgery: a systematic review and meta-analysis

Journal of Minimally Invasive Surgery
Purpose: Postoperative nausea and vomiting (PONV) is a prevalent and distressing complication, especially in laparoscopic surgeries. This review compares the efficacy and safety of palonosetron and ondansetron in preventing PONV after laparoscopic ...
Jitendra Kumar, Ragavi Alagarsamy, Babu Lal, Anshul J Rai, Rajnish Joshi, Sunaina Tejpal Karna, Prateek Shakti, Dinesh Kumar Verma, Vineeta Yadav, Pankaj Goel, Md. Yunus, Arivarasan Barathi   +11 more
doaj   +1 more source

Palonosetron-5-HT3 Receptor Interactions As Shown by a Binding Protein Cocrystal Structure

, 2016
Palonosetron is a potent 5-HT3 receptor antagonist and an effective therapeutic agent against emesis. Here we identify the molecular determinants of compound recognition in the receptor binding site by obtaining a high resolution structure of ...
Price, Kerry L., Lillestol, Reidun K., Lummis, Sarah C.R., Ulens, Chris   +3 more
core   +1 more source

A Comparative Study between Palonosetron and Granisetron to Prevent Postoperative Nausea and Vomiting after Laparoscopic Cholecystectomy [PDF]

Aim: This study aims to Compare Granisetron and Palonosetron for prevention of postoperative nausea and vomiting following laparoscopic surgery. Materials and Methods: This study was conducted on 80 patients in the Department of Anesthesiology, Critical ...
Faizan Khan
core   +1 more source

Comparison of Ramosetron and Palonosetron for Preventing Nausea and Vomiting after Spinal Surgery: Association With ABCB1 Polymorphisms

, 2017
BACKGROUND: Adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) polymorphisms may influence 5-hydroxytryptamine receptor antagonist efficacy by altering their efflux transportation.
최승호, 소사라, 송종욱, 심재광, 곽영란, 장재원   +5 more
core   +1 more source

Palonosetron Plus Dexamethasone in Highly Emetogenic Chemotherapy: Pooled Data from Two Phase III Trials

, 2013
Aim: Data from two randomized trials were pooled to further characterize the effectiveness of palonosetron combined with dexamethasone in the setting of highly emetogenic chemotherapy.
Celio, Luigi, Niger, Monica, Ricchini, Francesca, Braud, Filippo De, Agustoni, Francesco, Dotti, Katia   +5 more
core   +1 more source

Effects of Palonosetron on Perioperative Cardiovascular Complications in Patients Undergoing Noncardiac Surgery With General Anesthesia: A Retrospective Cohort Study

, 2015
We retrospectively investigated whether palonosetron administered during the induction of general anesthesia is associated with an increased risk of perioperative cardiovascular complications in a single tertiary center cohort consisting of 4,517 ...
김현주
core   +1 more source