Results 1 to 10 of about 853 (121)
Effects of N-alkyl quaternary quinuclidines on oxidative stress biomarkers in SH-SY5Y cells [PDF]
Arhiv za Higijenu Rada i ToksikologijuHaving a broad spectrum of biological and pharmacological activities, including anticholinergic, antihistaminic, antiparasitic, antioxidant, and antitumour, quinuclidine derivatives have piqued much interest in the field of drug discovery and biomedical ...
Zandona Antonio +4 more
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Quinuclidine Derivatives as Potential Antiparasitics [PDF]
Antimicrobial Agents and Chemotherapy, 2007 ABSTRACTThere is an urgent need for the development of new drugs for the treatment of tropical parasitic diseases such as Chagas' disease and leishmaniasis. One potential drug target in the organisms that cause these diseases is sterol biosynthesis. This paper describes the design and synthesis of quinuclidine derivatives as potential inhibitors of a ...
Cammerer, Simon B. +14 more
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(R)-(−)-Quinuclidin-3-ol [PDF]
Acta Crystallographica Section E Structure Reports Online, 2013 The structure of the title compound [alternatively called (R)-(−)-1-azabicyclo[2.2.2]octan-3-ol], C7H13NO, at 100 K has hexagonal (P61) symmetry. The structure shows a twist along the C—N pseudo-threefold axis. In the crystal, molecules are linkedviaO—H...N hydrogen bonds, forming infinite chains along thec-axis direction.
Rousselin, Yoann +2 more
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Squalene synthase as a target for Chagas disease therapeutics.
PLoS Pathogens, 2014 Trypanosomatid parasites are the causative agents of many neglected tropical diseases and there is currently considerable interest in targeting endogenous sterol biosynthesis in these organisms as a route to the development of novel anti-infective drugs.
Na Shang +23 more
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Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs
Interdisciplinary Perspectives on Infectious Diseases, 2009 Sterols are constituents of the cellular membranes that are essential for their normal structure and function. In mammalian cells, cholesterol is the main sterol found in the various membranes.
Wanderley de Souza +1 more
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Choice of an antihistamine administration route in the treatment of allergic diseases [PDF]
Терапевтический архив, 2016 Allergic diseases (AD) are an interdisciplinary problem in practical health care and characterized by high prevalence, severity, and huge financial costs of their treatment, prevention, and rehabilitation in patients.
L V Luss
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New and Potent Quinuclidine-Based Antimicrobial Agents [PDF]
Molecules, 2019 Developing new antibiotics is currently very important since antibiotic resistance is one of the biggest problems of global health today. In the search for a new class of potential antimicrobial agents, ten new compounds were designed and synthesized based on the quinuclidinium heterocyclic core and the oxime functional group.
Andreja Radman Kastelic +7 more
openaire +5 more sources
Arhiv za Higijenu Rada i ToksikologijuQuinuclidine derivatives are potent bioactive compounds investigated as cholinesterase inhibitors with potential intravenous therapeutic application.
Marcelić Lucija +4 more
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Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability. [PDF]
Int J Mol Sci, 2023 Žunec S +7 more
europepmc +1 more source
The Microwave Spectrum of Quinuclidine [PDF]
The Journal of Chemical Physics, 1960 openaire +1 more source