Results 1 to 10 of about 1,080 (176)
Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs [PDF]
Interdisciplinary Perspectives on Infectious Diseases, 2009 Sterols are constituents of the cellular membranes that are essential for their normal structure and function. In mammalian cells, cholesterol is the main sterol found in the various membranes.
Wanderley de Souza +1 more
doaj +8 more sources
Effects of N-alkyl quaternary quinuclidines on oxidative stress biomarkers in SH-SY5Y cells [PDF]
Arhiv za Higijenu Rada i ToksikologijuHaving a broad spectrum of biological and pharmacological activities, including anticholinergic, antihistaminic, antiparasitic, antioxidant, and antitumour, quinuclidine derivatives have piqued much interest in the field of drug discovery and biomedical ...
Zandona Antonio +4 more
doaj +2 more sources
New and potent quinuclidine based antimicrobial agents [PDF]
Molecules, 2019 Developing new antibiotics is currently very important since antibiotic resistance is one of the biggest problems of global health today. In the search for a new class of potential antimicrobial agents, ten new compounds were designed and synthesized ...
Hrenar, Tomica +7 more
core +6 more sources
The synthesis and application of functionalised quinuclidines [PDF]
, 2005 Hitchin, James Richard
core +2 more sources
Quinuclidine Derivatives as Potential Antiparasitics [PDF]
Antimicrobial Agents and Chemotherapy, 2007 ABSTRACTThere is an urgent need for the development of new drugs for the treatment of tropical parasitic diseases such as Chagas' disease and leishmaniasis. One potential drug target in the organisms that cause these diseases is sterol biosynthesis. This paper describes the design and synthesis of quinuclidine derivatives as potential inhibitors of a ...
Cammerer, Simon B. +14 more
openaire +4 more sources
(R)-(−)-Quinuclidin-3-ol [PDF]
Acta Crystallographica Section E Structure Reports Online, 2013 The structure of the title compound [alternatively called (R)-(−)-1-azabicyclo[2.2.2]octan-3-ol], C7H13NO, at 100 K has hexagonal (P61) symmetry. The structure shows a twist along the C—N pseudo-threefold axis. In the crystal, molecules are linkedviaO—H...N hydrogen bonds, forming infinite chains along thec-axis direction.
Rousselin, Yoann +2 more
openaire +2 more sources
Catalytic asymmetric approaches to nitrogen-containing bicycles [PDF]
, 2023 In this thesis, we report a series of asymmetric rhodium-catalysed Suzuki-Miyaura cross-coupling reactions between nitrogen-containing bicycles and boron species.
Zhang, Yan
core +2 more sources
A fluorinated quinuclidine benzamide named LMA 10203 acts as an agonist of insect nicotinic acetylcholine receptors [PDF]
, 2012 In the present study, we take advantage of the fact that cockroach dorsal unpaired median neurons express different nicotinic acetylcholine receptor subtypes to demonstrate that simple quinuclidine benzamides such as the 2-fluorinated benzamide LMA 10203,
B. Bodereau-Dubois +4 more
core +3 more sources
Squalene synthase as a target for Chagas disease therapeutics.
PLoS Pathogens, 2014 Trypanosomatid parasites are the causative agents of many neglected tropical diseases and there is currently considerable interest in targeting endogenous sterol biosynthesis in these organisms as a route to the development of novel anti-infective drugs.
Na Shang +23 more
doaj +1 more source
Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the α6 subtype [PDF]
, 2009 Direct comparison of pyridine versus pyrimidine substituents on a small but diverse set of ligands indicates that the pyrimidine substitution has the potential to enhance affinity and/or functional activity at α6 subunit-containing neuronal nicotinic ...
Bencherif, Merouane +7 more
core +1 more source