Results 21 to 30 of about 1,080 (176)
Recent Approaches for the Synthesis of Pyridine and Quinoline Cores Present in Natural Products
Advanced Synthesis &Catalysis, Volume 368, Issue 10, 19 May 2026.An anthology of the most recent methods used to synthesize pyridines and quinolines found in natural products over the last decade. Pyridines, quinolines, and their derivatives represent a class of significant heterocyclic compounds that are prevalent in a multitude of natural products, including alkaloids found in plants, fungi, insects, marine ...
Carl Bowman +2 more
wiley +1 more source
New Approaches for Chagas’ Disease Chemotherapy [PDF]
, 2018 The latest advances concerning drug design and chemotherapy development to combat the Chagas’ disease are discussed. This chapter is based on the metabolic differences between the pathogenic parasite and mammal hosts that led to the progress in the ...
Liñares, Guadalupe García
core +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.The enantioselective synthesis of naphthocoumarin adducts via a tandem organocatalytic 1,4‐addition/decarboxylation delivers excellent control over a newly forged stereocenter and yields configurationally stable synclinal atropisomers. The process features broad substrate scope and scalability, and its structural and mechanistic foundations are ...
M. Chiara Cabua +10 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.This work demonstrates a double desymmetrization of meso‐dicarboxylic acids with symmetrical olefins, constructing complex chiral lactones with six stereocenters in one step. Unexpectedly, the halide bond was found to be crucial in achieving high stereoselectivity.
Qingyu Zhang +3 more
wiley +2 more sources
Quantitative surface field analysis: learning causal models to predict ligand binding affinity and pose. [PDF]
, 2018 We introduce the QuanSA method for inducing physically meaningful field-based models of ligand binding pockets based on structure-activity data alone. The method is closely related to the QMOD approach, substituting a learned scoring field for a pocket ...
Cleves, Ann E, Jain, Ajay N
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Micro–Mesoporous Ferrierite: Strategies for Tuning the Accessibility of a Peculiar Zeolite
ChemCatChem, Volume 18, Issue 10, 27 May 2026.The anisotropic structure of ferrierite (FER) zeolite makes challenging the increase of catalyst effectiveness by hierarchical porosity. The pore mouth location of the active sites for butene isomerization requires a fine balance between development of external surface and retention of shape selectivity.
Jonathan Fabian Sierra‐Cantor +3 more
wiley +1 more source
Structural differences determine the relative selectivity of nicotinic compounds for native α4β2^*-, α6β2^*-, α3β4^*- and α7-nicotine acetylcholine receptors [PDF]
, 2010 Mammalian brain expresses multiple nicotinic acetylcholine receptor (nAChR) subtypes that differ in subunit composition, sites of expression and pharmacological and functional properties.
Bencherif, Merouane +10 more
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Chemistry – A European Journal, Volume 32, Issue 15, 22 April 2026.Staggered, square, and heavily bent dimers occur in the five known solvatomorphs of paddlewheel (PW) complex [PtVO(SOCPh)4]. These and other structural motifs are well within energetic reach due to the shallow potential energy surface that guides dimerization and are included in a revised classification of available structural data on heterobimetallic ...
Olga Mironova +3 more
wiley +1 more source
Parasite, Compartments, and Molecules: Trick versus Treatment on Chagas Disease [PDF]
, 2019 Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic to Latin America, standing out as a socio-economic problem for low-income tropical populations. Such disease affects millions of people worldwide and emerges in nonendemic areas due to
Brunoro, Giselle V. +4 more
core +2 more sources
Chemistry – A European Journal, Volume 32, Issue 13, 1 April 2026.This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley +1 more source