Results 21 to 30 of about 953 (169)

Synthesis and Activity of a Novel Series of 3-Biarylquinuclidine Squalene Synthase Inhibitors

, 2016
Quinuclidines with a 3-biaryl substituent are a new class of potent, orally active squalene synthase (SQS) inhibitors. Variants around these rigid structures indicate key structural requirements for cationic SQS inhibitors.
John McCormick (3018096), Susan Freeman (3018093), Peter J. Harrison (3018087), Keith B. Mallion (3018099), Graham J. Smith (2384353), Melvyn J. Taylor (3018084), David S. Clarke (1720234), Alan J. Foubister (3010476), Michael C. Johnson (1924801), Fergus McTaggart (3010473), Alan C. Reid (3018090), George R. Brown (3010470)   +11 more
core   +1 more source

Flipping the Card With Enantiodivergent Organocatalysis

Chemistry – A European Journal, Volume 32, Issue 29, 7 August 2026.
This minireview elaborates on recent organocatalytic strategies for achieving enantiodivergence—the ability to access both product enantiomers using a single chiral catalyst. It highlights how achiral stimuli, such as solvent polarity and chemical additives, along with minimal catalyst modifications, trigger stereochemical inversions in reactions ...
Debora Iapadre, Alessio Carioscia, Alessandro Brusa, Armando Carlone   +3 more
wiley   +1 more source

Using the Pyridine and Quinuclidine Scaffolds for Superbases: A DFT Study

, 2016
2,6-Disubstituted pyridines and 2,6,7-trisubstituted quinuclidines are screened as potential strong bases. The relative proton affinities of the bases are computed at PBE1PBE/6-311G(d,p) in the gas phase and in the solution phase (THF) at the same level ...
Cecily C. Wilbanks (187491), Steven M. Bachrach (1503883)   +1 more
core   +1 more source

Organocatalytic B–H Functionalization of Carboranes via Photo‐Induced Hydrogen Atom Transfer

ChemistryEurope, Volume 4, Issue 7, July 2026.
Visible‐light organocatalytic hydrogen atom transfer enables direct carborane B─H bond functionalization. A photocatalytically generated cationic aminium radical selectively abstracts hydrogen from hydridic boron sites, forming boron‐centered radicals that couple with activated olefins or imines to deliver B‐functionalized carboranes under mild ...
Takaya Sakaue, Kana Yasuda, Tsukasa Tawatari, Akira Matsumoto, Keiichi Hirano, Kiyosei Takasu, Hiroshi Takikawa   +6 more
wiley   +1 more source

Synthesis of Enantiopure 1-Azabicyclo[3.2.2]nonanes via Stereoselective Capture of Chiral Carbocations

, 2016
A new class of doubly functionalized and enantiomerically pure 1-azabicyclo[3.2.2]nonanes derived from quincorine and quincoridine is described. 2,5-Disubstituted quinuclidines with a C9-mesyloxy group were easily transformed into the corresponding ...
Stefanie Röper (2718766), H. M. R. Hoffmann (2702899), Olaf Schrake (3062475), Jens Frackenpohl (3049479), Rudolf Wartchow (2350843)   +4 more
core   +1 more source

Electron Donor–Acceptor Mediated Hydrosulfonylation of Olefins From N‐Hydroxymethylphthalimide Sulfones

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
Electron donor–acceptor complex formation between tertiary amines and N‐hydroxymethylphthalimide sulfones enables photocatalyst‐free hydrosulfonylation of olefins through light‐induced sulfinyl radical generation. Sulfones are widely used sulfur‐VI motifs in pharmaceuticals.
Makayla L. Williams, Twinkle I. Patel, Matthew J. Moschitto   +2 more
wiley   +1 more source

Ion‐Pairing and Counterion Effects in Contemporary Photochemistry

Angewandte Chemie Novit, Volume 2, Issue 2, June 2026.
Ion‐pairing and counterion effects have emerged as fundamental yet underexplored determinants of photochemical behavior. Far from inert, counterions, and Coulombic interactions modulate excited‐state dynamics, quenching efficiencies, emission, and catalytic pathways.
Matthias Schmitz, Christoph Kerzig
wiley   +1 more source

Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance

Chemistry – A European Journal, Volume 32, Issue 19, 22 May 2026.
This review covers the application of the bifunctional approach to photocatalysis as a means to attain (enhanced) enantioselectivity, and, more in general, as a strategy to enhance the catalytic performance through an effective use of short‐lived reaction intermediates.
Luigi Dolcini, Daniele Lavelli, Alberto Dal Corso, Luca Pignataro   +3 more
wiley   +1 more source

Recent Approaches for the Synthesis of Pyridine and Quinoline Cores Present in Natural Products

Advanced Synthesis &Catalysis, Volume 368, Issue 10, 19 May 2026.
An anthology of the most recent methods used to synthesize pyridines and quinolines found in natural products over the last decade. Pyridines, quinolines, and their derivatives represent a class of significant heterocyclic compounds that are prevalent in a multitude of natural products, including alkaloids found in plants, fungi, insects, marine ...
Carl Bowman, Mathieu Frenette, Sylvain Canesi   +2 more
wiley   +1 more source

Catalytic Enantioselective Synthesis of Conformationally Stable C(sp2)−C(sp3) Naphthocoumarin Atropisomers

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
The enantioselective synthesis of naphthocoumarin adducts via a tandem organocatalytic 1,4‐addition/decarboxylation delivers excellent control over a newly forged stereocenter and yields configurationally stable synclinal atropisomers. The process features broad substrate scope and scalability, and its structural and mechanistic foundations are ...
M. Chiara Cabua, Davide Moi, Emanuele Cocco, Valentina Onnis, Enrico Podda, David J. Aitken, Armando Carlone, Renzo Luisi, Enrica Tuveri, Drew F. Parsons, Francesco Secci   +10 more
wiley   +1 more source