Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides
Journal of Peptide Science, Volume 32, Issue 3, March 2026.As an alternative to the conventional approach, which combines amino acid monomers in a one‐by‐one fashion to peptide derivatives, the chemical modification of existing peptides has attracted significant attention in recent years. However, such approaches generally target the reactive functional groups in cysteine and lysine residues, particularly in ...
Yoshitaka Moriyama +2 more
wiley +1 more source
Novel nitrogen chemistry [PDF]
, 1999 Chapter One contains a brief overview of zeolites, their structure, uses and synthesis. Chapter Two relates to the attempted synthesis of quinuclidines via a novel 6-endo-trig radical cyclisation.
Wheildon, Andrew R.
core
Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals
Advanced Functional Materials, Volume 36, Issue 16, 23 February 2026.This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee +4 more
wiley +1 more source
Silver-Mediated Decarboxylation Reactions: Expanding Reaction Scope through Kinetic Analysis [PDF]
, 2020 Transition metal-catalyzed decarboxylative coupling reactions have received considerable attention in recent years as a method to obtain biaryl compounds.
Crovak, Robert Anthony
core +1 more source
Membrane therapy for chagas' disease [PDF]
, 2014 Currently, benznidazole and nifurtimox are the only drugs available for the specific treatment of Chagas’ disease. Both are limited by low efficacy in the chronic stage of the disease and considerable toxicity, which is why there is an urgent need for ...
Fügi, Matthias
core +1 more source
Asymmetric piperidine synthesis [PDF]
, 1995 It has been demonstrated that bakers' yeast reduction of 1-tert-butyl-2-methyl 3-oxo-piperidine-1,2-dicarboxylate gives (2R, 3S), 1-tert-butyl-2-methyl 3-hydroxy-piperidine-1,2-dicarboxylate in 80% chemical yield with >99% d.e. and >97% e.e. Also bakers'
Lewis, Neil
core
Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability. [PDF]
Int J Mol Sci, 2023 Žunec S +7 more
europepmc +1 more source
Crystal and molecular structures of new enantiopure quinuclidines
Chirality, 2004 AbstractX‐ray crystal structure analysis was performed on single crystals of two diastereomeric enantiopure quinuclidines, (3R,8R)‐3‐vinyl‐8‐hydroxymethyl‐quinuclidine (quincoridine, QCD) and (3R,8S)‐3‐vinyl‐8‐hydroxymethyl‐quinuclidine (quincorine, QCI) as their salts with tartaric and p‐toluenesulphonate anions, respectively.
Kania, Iwona +2 more
openaire +3 more sources
Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity [PDF]
, 2016 Toxoplasma gondii is a ubiquitous apicomplexan parasite capable of infecting humans and other animals. Current treatment options for T. gondii infection are limited and most have drawbacks, including high toxicity and low tolerability.
Davis, Paul H +6 more
core +2 more sources
Pharmacology of Organic Cation Transporters: Focus on Structure-Function Relationships in OCT3 (SLC22A3) [PDF]
, 2015 Organic Cation Transporters (OCTs) are polyspecific, facilitative transporters that play major roles in metabolite and drug clearance. OCTs are promising drug targets and elucidating their mechanisms of substrate recognition is crucial for rational drug ...
Li, Dan C
core +1 more source