Results 31 to 40 of about 1,080 (176)
Direct Access to Acylboranes via Formal Condensation of Carboxylic Acids with Ligated Boranes
Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.A nickel‐catalyzed, radical‐based C(acyl)–B cross‐coupling strategy has been developed for the efficient synthesis of bench‐stable, phosphonite‐ligated acylborane compounds from readily available carboxylic acids. This methodology not only provides access to acylboranes with diverse reactivity profiles but also establishes a versatile platform for the ...
Chen‐Yan Cai +5 more
wiley +2 more sources
Macromolecular Rapid Communications, Volume 47, Issue 7, 3 April 2026.Quinuclidine, as a tertiary amine, can rapidly polymerize epoxy groups. We investigated the relationship between amine properties and polymerization behavior by monitoring the reactions of various tertiary amines with epoxy groups. The results indicate that quinuclidine, the most nucleophilic amine examined, promotes epoxy polymerization.
Yukai Ito, Daisuke Aoki, Koji Arimitsu
wiley +1 more source
Recent Progress in the Development of Small-Molecule FtsZ Inhibitors as Chemical Tools for the Development of Novel Antibiotics [PDF]
, 2019 Antibiotics are potent pharmacological weapons against bacterial pathogens, nevertheless their efficacy is becoming compromised due to the worldwide emergence and spread of multidrug-resistant bacteria or “superbugs”.
Carro, Laura
core
Synthesis and Biological Evaluation of New Substituted 3-[4-(Phenylsulfonamido)benzoyl]-2 H [PDF]
, 2014 A series of new substituted 3-[4-(phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one derivatives bearing groups methoxy, tert-butyl, and atoms of halogens at the para-position of the A-ring were synthesized and in vitro biological activities were evaluated
Fan-hao Meng +4 more
core +2 more sources
Bis‐Furans: A Sustainable Source of Diverse Molecular Architectures
European Journal of Organic Chemistry, Volume 29, Issue 10, 9 March 2026.A concise synthetic route to diverse acyclic and heterocyclic compounds has been developed by combining hetero‐Diels–Alder reactions, DBU‐promoted ring openings, and Lewis base‐catalyzed annulations. Nitrosoalkenes reacted with furan derivatives to form 4a,7a‐dihydro‐4H‐furo[2,3‐e][1,2]oxazines, which underwent DBU‐promoted rearrangements to 6H‐1,2 ...
Ana L. Cardoso +2 more
wiley +1 more source
Indeed, No Need for HMPA! A DFT Study Comparing the Lewis Basicity of Phosphoric Acid Triamides
ChemistryEurope, Volume 4, Issue 3, March 2026.High‐level density functional theory calculations of the interactions of protons, lithium cations, and samarium(II) and samarium(III) species with a series of Lewis bases reveal that TPPA and HAPO‐2 are stronger donor compounds than HMPA. Therefore, they should by excellent substitutes of carcinogenic and mutagenic HMPA in many reactions.
Luca Steiner +3 more
wiley +1 more source
Identification of the Initial Steps in Signal Transduction in the α4β2 Nicotinic Receptor:Insights from Equilibrium and Nonequilibrium Simulations [PDF]
, 2019 Nicotinic acetylcholine receptors (nAChRs) modulate synaptic transmission in the nervous system. These receptors have emerged as therapeutic targets in drug discovery for treating several conditions, including Alzheimer's disease, pain, and nicotine ...
Campello, Hugo Rego +6 more
core +2 more sources
Targeting bacterial cell division: A binding site-centered approach to the most promising inhibitors of the essential protein FtsZ [PDF]
, 2020 Binary fission is the most common mode of bacterial cell division and is mediated by a multiprotein complex denominated the divisome. The constriction of the Z-ring splits the mother bacterial cell into two daughter cells of the same size.
A. Casiraghi +3 more
core +1 more source
Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi +2 more
wiley +1 more source
Investigation into the bioisosteric approach in the design, synthesis and evaluation of muscarinic receptor ligands [PDF]
, 2013 The acetylcholine (ACh) receptor system belongs to rhodopsin GPCR family and is an integral membrane protein divided into two types: muscarinic and nicotinic. The naturally occurring neurotransmitter acetylcholine binds to these two receptor systems non-
Bhandare, Richie R.
core +1 more source