Results 21 to 30 of about 69,133 (199)

El salvaje y su tratamiento en el discurso político argentino sobre la frontera sur, 1853-1879

open access: yesRevista de Indias, 2001
El concepto de salvaje fue utilizado para denominar a quienes se resistieron, en la segunda mitad del siglo XIX, a la consolidación del Estado argentino.
Pedro Navarro Floria
doaj   +1 more source

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

open access: yesAngewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey   +13 more
wiley   +2 more sources

Backbone Steric Constraints Underlie High Passive Membrane Permeability of N‐Alkyl Peptides

open access: yesAngewandte Chemie, EarlyView.
Beyond amide hydrogen removal, steric constraints encoded in N/Cα‐dually substituted backbones are uncovered as a key determinant of passive membrane permeability in N‐alkyl peptides. These constraints restrict conformational freedom and sterically limit backbone hydration during membrane permeation.
Ayumi Inayoshi   +8 more
wiley   +2 more sources

Caciques, jesuitas y chamanes en la frontera sur de Buenos Aires (1740-1753)

open access: yesAnuario de Estudios Americanos, 2003
El artículo analiza la evolución de tres misiones fundadas por la compañía de Jesús al sur del río Salado, en la gobernación de Buenos Aires, entre los años 1741 y 1753.
Raúl Hernández Asensio
doaj   +1 more source

Preliminary Appraisal of a Correlation Between Glaciations and Large Igneous Provinces Over the Past 720 Million Years

open access: yesGeophysical Monograph Series, Page 169-190., 2021

Exploring the links between Large Igneous Provinces and dramatic environmental impact

An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
Nasrrddine Youbi   +9 more
wiley  

+1 more source

Evaluation of the Ability of PAMPA Membranes to Emulate Biological Processes through the Abraham Solvation Parameter Model

open access: yesMembranes, 2023
Two parallel artificial membrane permeability assay (PAMPA) systems intended for emulating skin permeability have been characterized through the solvation parameter model of Abraham using multilinear regression analysis.
Sara Soriano-Meseguer   +3 more
doaj   +1 more source

Permeation characteristics of tetracyclines in parallel artificial membrane permeation assay II: Effect of divalent metal ions and mucin

open access: yesADMET and DMPK, 2020
The bioavailability of tetracyclines is markedly decreased when co-administered with antacids, milk, or food containing Ca2+. Previously, it was suggested that the effective intestinal permeation of tetracycline (TC) was decreased due to Ca2+ linked ...
Sachika Yamauchi   +2 more
doaj   +1 more source

Programa de rádio Ecos do Pampa: Diálogo de saberes sobre plantas nativas

open access: yesRevista Brasileira de Extensão Universitária, 2023
O Bioma Pampa é um mosaico de paisagens campestres e florestais. Nas últimas duas décadas a biodiversidade intrínseca a esses ecossistemas vem sofrendo forte ameaça devido à pressão no uso da terra por atividades agropecuárias. Uma alternativa para essa
Stefany Areva Severo   +2 more
doaj   +1 more source

La pregunta por el autor en Bajtín

open access: yesBakhtiniana: Revista de Estudos do Discurso, 2014
Quisiera reflexionar sobre el problema del autor en Bajtín que es objeto de numerosos asedios a lo largo de su obra: como personaje, como ideólogo de la arquitectónica, como voz enmascarada, como oído polifónico, como interlocutor en diálogo ...
Pampa Olga Arán
doaj   +3 more sources

Habitar La Pampa en la palabra: la creación poética del salitre

open access: yesRevista de Ciencias Sociales, 2003
En este artículo el autor explica el surgimiento de la creación poética en el desierto de Atacama durante el desarrollo del período salitrero. El autor hace una distinción entre “pampa” y desierto, donde la primera está relacionada con el “habitar” y la
Sergio González
doaj   +1 more source

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