Results 21 to 30 of about 31,089 (264)

In silico model-based exploration of the applicability of parallel artificial membrane permeability assay (PAMPA) to screen chemicals of environmental concern.

Environment International, 2022
Parallel Artificial Membrane Permeability Assay (PAMPA) is an in vitro laboratory method for screening the transmembrane permeability of chemicals. Stemming from medicinal chemistry, PAMPA has the potential for use in the cost-effective high-throughput ...
Shenghong Wang, Zhizhen Zhang, Dingsheng Li, S. E. Illa, Li Li   +4 more
semanticscholar   +1 more source

Brazilian Atlantic Forest and Pampa Biomes in the spotlight: an overview of Aspergillus, Penicillium, and Talaromyces (Eurotiales) species and the description of Penicillium nordestinense sp. nov.

Acta Botânica Brasílica, 2022
The knowledge of the geographical distribution of fungi is essential to promote the understanding of global and national fungal diversity patterns. In this study, we provide a literature-based checklist of Aspergillus , Penicillium , and Talaromyces ...
R. N. Barbosa, J. E. F. D. Santos, J. Bezerra, Ł. Istel, J. Houbraken, N. T. Oliveira, C. Souza-Motta   +6 more
semanticscholar   +1 more source

Application of in vitro PAMPA technique and in silico computational methods for blood-brain barrier permeability prediction of novel CNS drug candidates.

European Journal of Pharmaceutical Sciences, 2021
Permeability assessment of small molecules through the blood-brain barrier (BBB) plays a significant role in the development of effective central nervous system (CNS) drug candidates. Since in vivo methods for BBB permeability estimation require a lot of
Mila Radan, Teodora Djikić, D. Obradović, K. Nikolić   +3 more
semanticscholar   +1 more source

Development of Meloxicam-Human Serum Albumin Nanoparticles for Nose-to-Brain Delivery via Application of a Quality by Design Approach

Pharmaceutics, 2020
The aim of this study was to optimize the formulation of meloxicam (MEL)-containing human serum albumin (HSA) nanoparticles for nose-to-brain via a quality by design (QbD) approach.
Gábor Katona, György Tibor Balogh, Gergő Dargó, Róbert Gáspár, Árpád Márki, Eszter Ducza, Anita Sztojkov-Ivanov, Ferenc Tömösi, Gábor Kecskeméti, Tamás Janáky, Tamás Kiss, Rita Ambrus, Edina Pallagi, Piroska Szabó-Révész, Ildikó Csóka   +14 more
doaj   +1 more source

Rainfall extremes modeling under shortage of data and uncertainty in the Pampean region (Argentina)

Cuadernos de Investigación Geográfica, 2018
The assessment of the surface runoff capacity of storms is essential for the design of drainage infrastructure, for the management of rainfall excesses and the control of soil erosion. The knowledge of precipitation intensity values at scales larger than
M. Puricelli
doaj   +1 more source

Cavioids, Chinchilloids, and Erethizontoids (Hystricognathi, Rodentia, Mammalia) of the Early Miocene Pampa Castillo Fauna, Chile

American Museum Novitates, 2022
Caviomorph rodents became important components of South American faunas after their Eocene arrival from Africa. Here we describe the cavioid, chinchilloid, and erethizontoid caviomorphs of the early Miocene Pampa Castillo fauna of southern Chile.
A. McGrath, J. Chick, D. Croft, Holly E. Dodson, J. J. Flynn, A. Wyss   +5 more
semanticscholar   +1 more source

Procesos de subalternización de la población indígena en Argentina: los ranqueles en La Pampa, 1870-1970

Revista de Indias, 2011
A partir de las campañas militares de 1878-1885, conocidas en Argentina como «Conquista del Desierto», las poblaciones indígenas ensayaron distintas estrategias para enfrentar las condiciones adversas y las políticas que pretendían su subalternización e ...
Claudia Salomón Tarquini
doaj   +1 more source

A mechanistic study of drug mass transport from supersaturated solutions across PAMPA membranes.

Journal of Pharmacy and Science, 2021
There is an increasing shift from dissolution testing to dissolution-permeation testing of formulations during formulation development and this has led to rise in the application of permeability measurements using parallel artificial membrane ...
Siddhi S. Hate, Laura I. Mosquera-Giraldo, L. Taylor   +2 more
semanticscholar   +1 more source

A corneal-PAMPA-based in silico model for predicting corneal permeability.

Journal of Pharmaceutical and Biomedical Analysis, 2021
The capability to predict corneal permeability based on physicochemical parameters has always been a desirable objective of ophthalmic drug development.
A. Vincze, Gergő Dargó, Anita Rácz, G. Balogh   +3 more
semanticscholar   +1 more source

Caciques, jesuitas y chamanes en la frontera sur de Buenos Aires (1740-1753)

Anuario de Estudios Americanos, 2003
El artículo analiza la evolución de tres misiones fundadas por la compañía de Jesús al sur del río Salado, en la gobernación de Buenos Aires, entre los años 1741 y 1753.
Raúl Hernández Asensio
doaj   +1 more source