Results 41 to 50 of about 69,133 (199)

Artificial tissue binding models : development and comparative evaluation of high - throughput lipophilicity assays and their use for PET tracer optimization [PDF]

, 2015
The purpose of this thesis was to increase the efficiency of the Positron Emission Tomography (PET) tracer development process. Since many neuroimaging agents fail due to undesirably high non-specific binding (NSB) to brain tissue, we aimed at estimating
Assmus, Frauke
core   +1 more source

Biomimetic Artificial Membrane Permeability Assay over Franz Cell Apparatus Using BCS Model Drugs

Pharmaceutics, 2020
A major parameter controlling the extent and rate of oral drug absorption is permeability through the lipid bilayer of intestinal epithelial cells. Here, a biomimetic artificial membrane permeability assay (Franz–PAMPA Pampa) was validated using a Franz ...
Leonardo de Souza Teixeira, Tatiana Vila Chagas, Antonio Alonso, Isabel Gonzalez-Alvarez, Marival Bermejo, James Polli, Kênnia Rocha Rezende   +6 more
doaj   +1 more source

Segmental composition and nerve distribution of the brachial plexus in Galictis cuja

The Anatomical Record, EarlyView.
Abstract Galictis cuja is a neotropical mustelid with terrestrial locomotor habits, yet the anatomy of its brachial plexus has remained undescribed. This study characterizes the origin, organization, and distribution of the brachial plexus nerves in 15 adult specimens (30 antimeres).
Natan da Cruz de Carvalho, Thais Mattos Estruc, Ingrid Bete Palmeira, Julia Fagundes Franco, Emillin Reis Bermudez, Paulo de Souza‐Junior, Marcelo Abidu‐Figueiredo   +6 more
wiley   +1 more source

Cyclic peptide membrane permeability prediction using deep learning model based on molecular attention transformer

Frontiers in Bioinformatics
Membrane permeability is a critical bottleneck in the development of cyclic peptide drugs. Experimental membrane permeability testing is costly, and precise in silico prediction tools are scarce.
Dawei Jiang, Zixi Chen, Zixi Chen, Hongli Du   +3 more
doaj   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Monk’s tonsure-like gaps in the tussock grass Spartina argentinensis (Gramineae)

Revista de Biología Tropical, 2001
Monk's tonsure-like gaps develop inside gramineans and other plants. The tonsures of Spartina argentinensis originate as a result of tussock development and disturbance.
J. P. Lewis, S. L. Stofella, S. R. Feldman   +2 more
doaj  

Phytochemistry, Chemotypic Diversity and Antimicrobial Potential of Essential Oils From Native Aromatic Plants of the Americas: A Systematic Review

Flavour and Fragrance Journal, EarlyView.
This review bridges ancestral indigenous knowledge with modern pharmacology, summarizing the phytochemistry and antimicrobial properties of essential oils from seven native American species. It highlights their significant activity against bacterial, fungal and parasitic pathogens, emphasizing their potential as sustainable therapeutic and agricultural
Arley Rey Páez, Mozaniel Santana de Oliveira, João Paulo Viana Leite   +2 more
wiley   +1 more source

Health Biomarkers of Pesticide Exposure in Rural Populations of Santa Fe, Argentina: Oxidative Stress and Genotoxicity

Journal of Applied Toxicology, EarlyView.
ABSTRACT The present study aimed to quantify pesticide residues in environmental matrices and plasma and to evaluate their potential effects on oxidative stress and DNA damage in rural populations of Santa Fe province. Soil and rainwater samples were collected, and biological samples and semistructured surveys were obtained from volunteers in three ...
María Priscila Dechiara, Carlina Leila Colussi, Lucía Magdalena Odetti, Damián Marino, María Fernanda Simoniello   +4 more
wiley   +1 more source

Argentinian Identity and the Frontier: Foreigners, Indians and a «gaucho insufrible»

1616, 2011
After the independence fight against Spain, the new Argentine Republic found another border, but this time in the inside. The limit between Civilization and Barbarism is also the frontier between two worlds, one of them inhabitated by men they don’t ...
Raquel ARIAS CAREAGA
doaj  

Machine Learning‐Based Correction of Reanalysis Surface Radiation Fluxes Using Ground‐Measured Data in the Southern Brazilian Pampa Biome

International Journal of Climatology, EarlyView.
This study demonstrates that ERA5 provides more accurate surface radiation flux estimates than MERRA2 across the Southern Brazilian Pampa. Machine learning models, particularly Random Forest, further improved the precision of reanalysis data for climate applications.
Olusola Samuel Ojo, Michel Baptistella Stefanello, Alecsander Mergen, Maria Eduarda Oliveira Pinheiro, Vanessa de Arruda Souza, Débora Regina Roberti   +5 more
wiley   +1 more source