Results 281 to 290 of about 256,370 (362)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

TB will never end because of us: Experiences of TB preventive treatment among people living with HIV/AIDS in South Africa. [PDF]

PLoS One
Mlambo LM, Setlaleleng M, Shearer K, Mofokeng NJ, Ndou P, Milovanovic M, Steiner L, Genade L, Lebina L, Martinson NA, Hoffmann CJ, Owczarzak J.   +11 more
europepmc   +1 more source

Voter Pamphlets: The Next Best Step in Election Reform

, 2002
Peter Brien
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Evaluating the Effectiveness of Parent Training Pamphlets: An Intervention Study Among Parents at Child Health Checkups. [PDF]

J Prim Care Community Health
Akutsu K, Goto A, Abo-Rass F, Yokoyama H.   +3 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Designing and implementing the intervention to promote brucellosis prevention behaviors in ranchers and their family members in the rural areas in East North Iran: Application of precede-proceed model. [PDF]

J Educ Health Promot
Vahedian-Shahroodi M, Tehrani H, Alizadeh-Siuki H.   +2 more
europepmc   +1 more source

Foundations for Freedom of Conscience: Stronger than You Might Think [PDF]

, 2005
Brady, Kathleen A.
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Improving oral health service delivery: the patient perspective. [PDF]

Prim Health Care Res Dev
Chakaipa S, Van Dam PJ, Prior SJ.
europepmc   +1 more source