Results 91 to 100 of about 3,204,397 (250)

Transmission of multidrug-resistant tuberculosis in the UK: a cross-sectional molecular and epidemiological study of clustering and contact tracing [PDF]

, 2014
BACKGROUND: Between 2000 and 2012 the number of multidrug-resistant (MDR) tuberculosis cases in the UK increased from 28 per year to 81 per year. We investigated the proportion of MDR tuberculosis cases arising from transmission in the UK and associated ...
Abubakar, Ibrahim, Anderson, Laura F, Brown, Timothy, Watson, JP, Abubakar, I, Tamne, Surinder, Mullarkey, C, Anderson, LF, Tamne, S, Zenner, D, Brown, T, Mullarkey, Catherine, Watson, John P, Zenner, Dominik   +13 more
core   +1 more source

Transferable drug resistance plasmids in fish-pathogenic bacteria [PDF]

, 2000
Chemotherapeutic agents have been developed for treating bacterial infections and have been widely used for cultured fish for the last 30 years in Japan.
Aoki, Takashi
core   +1 more source

Pan-drug-resistant and biofilm-producing strain of Burkholderia pseudomallei: first report of melioidosis from a diabetic patient in Yogyakarta, Indonesia [Letter]

International Medical Case Reports Journal, 2019
 David AB Dance,1 Vanaporn Wuthiekanun,2 Derek Sarovich,3 Erin P Price,3 Direk Limmathurotsakul,4 Bart J Currie,5 Trinh Thanh Trung61Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Lao PDR; 2Mahidol-Oxford Tropical Medicine ...
Dance DA, Wuthiekanun V, Sarovich D, Price EP, Limmathurotsakul D, Currie BJ, Trung TT   +6 more
doaj  

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. [PDF]

, 2008
BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Hastings, Ian M, Day, Nicholas PJ, White, Nicholas J., Dondorp, AM, Hastings, Ian M., Dondorp, Arjen M, Dondorp, Adrianus, Hastings, Ian, Day, Nicholas P. J., Pongtavornpinyo, W, Hastings, IM, Pongtavornpinyo, Wirichada, White, Nicholas J, Day, Nicholas, Day, Nicholas P.J., Yeung, Shunmay, Day, NP, White, NJ, White, Nicholas, Dondorp, Arjen M., Yeung, S, Hastings Ian M, Dondorp Arjen M, Pongtavornpinyo Wirichada, Day Nicholas PJ, Yeung Shunmay, White Nicholas J   +26 more
core   +1 more source

PDGFRα+/Integrin α2+ Fibroblasts Orchestrate Tumor Budding in Oral Squamous Cell Carcinoma via Mechano‐Metabolic Symbiosis: E‐Cadherin/Integrin α2β1 Adhesion and Mitochondrial Transfer

Advanced Science, EarlyView.
PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu, Jiao Li, Juan Liu, Qi Dong, Haoyang Zhang, Yanjin Wang, Huibing Li, Ye Guan, Lei Cao, Manqing Zhang, Fangning Guo, Xue Liu, Zhen Yang, Mengmeng Lu, Hui Liu, Laiping Zhong, Tong Ji, Tingjiao Liu   +17 more
wiley   +1 more source

Clinical management of drug-resistant tuberculosis in resource constrained settings [PDF]

, 2013
Drug-resistant forms of tuberculosis (TB), particularly multi- and extensively drug-resistant TB, represent an important obstacle to global control of the disease. Recently, new drugs, repurposed drugs, and new drug combinations have been evaluated, with
Palmero, Domingo, Ritacco, Gloria Viviana   +1 more
core   +1 more source

Characterisation and modulation of drug resistance in lung cancer cell lines [PDF]

, 2010
Chemotherapy drug resistance is a major obstacle in the treatment of cancer. It can result from an increase in levels of cellular drug efflux pumps such as P-glycoprotein (P-gp).
Dunne, Gráinne
core   +2 more sources

A Novel Antimicrobial Peptide Displaying Broad-Spectrum Activity Against Pan-Resistant Pathogens and Low Propensity for Resistance Development

Antibiotics
Objectives: The escalation of multidrug-resistant (MDR) clinically relevant bacterial isolates, including Escherichia coli and key ESKAPE pathogens, represents a critical global healthcare threat.
Betul Zehra Temur, Esma Bolat, Meltem Ayas, Sengül Nisa Demirci, Nihan Unubol, Neval Yurttutan Uyar, Ozge Can, Tanil Kocagoz   +7 more
doaj   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source