Results 111 to 120 of about 3,204,397 (250)

Models of Virus-Immune Dynamics and Drug Resistant Virus Infections

, 2006
Models for the activity of a virus within a host describe the interaction between virus, the cells they infect and the attempts of the body's immune response to remove the infection. We aim to improve these models by incorporating more detailed, and more
Soberano, Lisa Albert
core  

Possible risk factors and outcomes of Multi-Drug Resistant (MDR) and Extensively- Drug Resistant (XDR) infections (Pan-drug Resistant infections were not considered due to the small sample size).

, 2015
Possible risk factors and outcomes of Multi-Drug Resistant (MDR) and Extensively- Drug Resistant (XDR) infections (Pan-drug Resistant infections were not considered due to the small sample size).
Mario Venditti (720419), Alessio Farcomeni (636585), Manuela Merli (742820), Michela Giusto (742825), Oliviero Riggio (742826), Valerio Giannelli (742823), Barbara Lattanzi (742824), Marco Falcone (720412), Cristina Lucidi (742821), Vincenza Di Gregorio (742822), Giancarlo Ceccarelli (648611)   +10 more
core   +1 more source

Sequential Immune Acquisition of Monoclonal Antibodies Enhances Phagocytosis of Acinetobacter baumannii by Recognizing ATP Synthase

Vaccines
Objectives: The aim of this study was to prepare monoclonal antibodies (mAbs) that broadly target Acinetobacter baumannii and protect against infection by multi-drug-resistant (MDR) A. baumannii from different sources.
Dong Huang, Zhujun Zeng, Zhuolin Li, Mengjun Li, Linlin Zhai, Yuhao Lin, Rui Xu, Jiuxin Qu, Bao Zhang, Wei Zhao, Chenguang Shen   +10 more
doaj   +1 more source

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

Drug-resistant Tuberculosis [PDF]

Type: BacteriaAlso known as: TB, multidrug-resistant TB (MDR TB), or extensively drug-resistant TB (XDR TB), Mycobacterium tuberculosis (M. tuberculosis)About: TB is caused by the bacteria M. tuberculosis, and is among the most common infectious diseases

core  

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Case Report: Pan-Drug Resistant Pseudomonas aeruginosa from a Child with an Infected Burn Wound at the University Teaching Hospital of Kigali, Rwanda [PDF]

Innocent Ndikubwimana,1 Noel Gahamanyi,2,3 Thaddée Bwanakweli,2 Henri Desire Uwayo,2 Gaspard Habimana,4 Tanya Rogo5 1Pediatric Department, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda; 2National Reference Laboratory ...
Gahamanyi N, Rogo T, Ndikubwimana I, Uwayo HD, Bwanakweli T, Habimana G   +5 more
core  

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

The Lancet Respiratory Medicine Commission : 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis

, 2019
: The Lancet Respiratory Medicine Commission on drug-resistant tuberculosis was published in 2017, which comprehensively reviewed and provided recommendations on various aspects of the disease.
Dowdy, David, Nuermberger, Eric, Chang, Kwok Chiu, Migliori, G.B., Furin, Jennifer, Limberis, Jason, Menzies, Dick, McIlleron, Helen, Jindani, Amina, Jaramillo, Ernesto, McNerney, Ruth, Nardell, Edward A., Dooley, Kelly E., Schaaf, H. Simon, Barry, Clifton E., Van Rie, Annelies, Ndjeka, Norbert, Keshavjee, Salmaan, Rodrigues, Camilla, Low, Marcus, Lange, Christoph, Padayatchi, Nesri, Nahid, Payam, Nunn, Andrew, Sirgel, Frik A., Warren, Robin M., Udwadia, Zarir F., Lessem, Erica, Maartens, Gary, Horsburgh, C. Robert, Esmail, Aliasgar, Clark, Taane G., Murray, Megan, Seddon, James A., Pasipanodya, Jotam G., Gumbo, Tawanda, Niemann, Stefan, Dheda, Keertan, Churchyard, Gavin J., London, Leslie, Theron, Grant, Fourie, Bernard, Fennelly, Kevin P., Hesseling, Anneke C.   +43 more
core  

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source