Results 121 to 130 of about 641,720 (354)

A case of pancreatic head cancer with Trousseau’s syndrome treated with radical resection and anticoagulant therapy

Surgical Case Reports, 2023
Background The primary disease of Trousseau’s syndrome is often highly advanced cancer, and treatment of the primary disease after cerebral infarction is often difficult. We herein report a case of pancreatic head cancer with Trousseau’s syndrome treated
Takumi Kitahama, Shimpei Otsuka, Teiichi Sugiura, Ryo Ashida, Katsuhisa Ohgi, Mihoko Yamada, Katsuhiko Uesaka   +6 more
doaj   +1 more source

Autophagy in Pancreatic Cancer [PDF]

International Journal of Cell Biology, 2012
Pancreatic adenocarcinoma (PDAC) is a devastating disease with an extremely poor life expectancy and no effective treatment. Autophagy is a process of degradation of cytoplasmic component capable of recycling cellular components or eliminate specific targets. The presence of autophagy in PDAC has been demonstrated.
Daniel Grasso, Maria Noé Garcia, Juan L. Iovanna   +2 more
openaire   +4 more sources

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Pancreatic Cancer: Surgery of pancreatic cancer

Annals of Oncology, 1994
Pancreatic cancer which has an increasing incidence in the western countries is associated with an especially poor prognosis. This is mainly due to the low proportion of early and radically resectable stages, when diagnosed. Patients with irresectable disease have a median survival time of 3-4 months and their prognosis is not essentially improved by ...
openaire   +2 more sources

Cost-effectiveness of diagnostic laparoscopy for assessing resectability in pancreatic and periampullary cancer. [PDF]

, 2015
Surgical resection is the only curative treatment for pancreatic and periampullary cancer, but many patients undergo unnecessary laparotomy because tumours can be understaged by computerised tomography (CT).
Davidson, BR, Gurusamy, KS, Morris, S, Sheringham, J   +3 more
core   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Predicting the risk of pancreatic cancer with a CT-based ensemble AI algorithm [PDF]

arXiv, 2020
Objectives: Pancreatic cancer is a lethal disease, hard to diagnose and usually results in poor prognosis and high mortality. Developing an artificial intelligence (AI) algorithm to accurately and universally predict the early cancer risk of all kinds of pancreatic cancer is extremely important.
arxiv  

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, incurable cancer with a 20% 1 year survival rate. While standard-of-care therapy can prolong life in a small fraction of cases, PDAC is inherently resistant to current treatments, and novel ...
Adile, Ashley A., Bakhshinyan, David, Berger-Becvar, Angelika, de Araujo, Elvin D., Deininger, Michael W., Fishel, Melissa L., Gawel, Justyna M., Geletu, Mulu, Grimard, Michelle L., Gunning, Patrick T., Heaton, William L., Konieczny, Stephen F., Luchman, H. Artee, O'Hare, Thomas, Raouf, Yasir, Shah, Fenil, Shouksmith, Andrew E., Singh, Sheila K., Venugopal, Chitra, Weiss, Samuel   +19 more
core   +3 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Pancreatic cysts suspected to be branch duct intraductal papillary mucinous neoplasm without concerning features have low risk for development of pancreatic cancer. [PDF]

, 2015
BackgroundThe risk of developing pancreatic cancer is uncertain in patients with clinically suspected branch duct intraductal papillary mucinous neoplasm (BD-IPMN) based on the "high-risk stigmata" or "worrisome features" criteria proposed in the 2012 ...
Fehmi, Syed A, Giap, Andrew Q, Gonzalez, Ingrid, Hunt, Gordon C, Krinsky, Mary L, Kwong, Wilson T, Lawson, Robert D, Savides, Thomas J, Slezak, Jeff, Tang, Raymond S   +9 more
core   +1 more source